Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity

Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity

Gonorrhea, which is caused by Neisseria gonorrhoeae, is the second most reported sexually transmitted infection worldwide. The increasing appearance of isolates that are resistant to approved therapeutics raises the concern that gonorrhea may become untreatable. Here, we serendipitously identified o...

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Bibliographic Details
Main Authors: Jingbo Kan, Adrian Morales-Amador, Yozen Hernandez, Melinda A Ternei, Christophe Lemetre, Logan W Maclntyre, Nicolas Biais, Sean F Brady
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
Neisseria gonorrhoeae
cell culture
antibiotics
Online Access:https://elifesciences.org/articles/99281
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