Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.

Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.

Apoptosis is an essential defensive mechanism against tumorigenesis. Proteins of the B-cell lymphoma-2 (Bcl-2) family regulate programmed cell death by the mitochondrial apoptosis pathway. In response to intracellular stress, the apoptotic balance is governed by interactions of three distinct subgro...

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Bibliographic Details
Main Authors: Simon Mathis Kønig, Vendela Rissler, Thilde Terkelsen, Matteo Lambrughi, Elena Papaleo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-12-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007485&type=printable
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