Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury
Introduction. A total of 18 patients, with complete motor deficits and paraplegia caused by thoracic and lumbar spine trauma without muscle atrophy or psychiatric problems, were included into this study. Materials and Methods. The bone marrow was aspirated from the anterior iliac crest under local a...
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6768274 |
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| author | Zurab Kakabadze Nickolas Kipshidze Konstantine Mardaleishvili Gocha Chutkerashvili Irakli Chelishvili Albrecht Harders George Loladze Gocha Shatirishvili Nodar Kipshidze David Chakhunashvili Konstantine Chutkerashvili |
| author_facet | Zurab Kakabadze Nickolas Kipshidze Konstantine Mardaleishvili Gocha Chutkerashvili Irakli Chelishvili Albrecht Harders George Loladze Gocha Shatirishvili Nodar Kipshidze David Chakhunashvili Konstantine Chutkerashvili |
| author_sort | Zurab Kakabadze |
| collection | DOAJ |
| description | Introduction. A total of 18 patients, with complete motor deficits and paraplegia caused by thoracic and lumbar spine trauma without muscle atrophy or psychiatric problems, were included into this study. Materials and Methods. The bone marrow was aspirated from the anterior iliac crest under local anesthesia and the mononuclear fraction was isolated by density gradient method. At least 750 million mononuclear-enriched cells, suspended in 2 mL of saline, were infused intrathecally. Results and Discussion. The study reports demonstrated improvement of motor and sensory functions of various degrees observed in 9 of the 18 (50%) cases after bone marrow stem cell transplantation. Measured by the American Spinal Injury Association (ASIA) scale, 7 (78%) out of the 9 patients observed an improvement by one grade, while two cases (22%) saw an improvement by two grades. However, there were no cases in which the condition was improved by three grades. Conclusions. Analysis of subsequent treatment results indicated that the transplantation of mononuclear-enriched autologous BMSCs is a feasible and safe technique. However, successful application of the BMSCs in the clinical practice is associated with the necessity of executing more detailed examinations to evaluate the effect of BMSCs on the patients with spinal cord injury. |
| format | Article |
| id | doaj-art-6d6d76124e7c4931950738a9707ca979 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6d6d76124e7c4931950738a9707ca9792025-02-03T05:58:16ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/67682746768274Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord InjuryZurab Kakabadze0Nickolas Kipshidze1Konstantine Mardaleishvili2Gocha Chutkerashvili3Irakli Chelishvili4Albrecht Harders5George Loladze6Gocha Shatirishvili7Nodar Kipshidze8David Chakhunashvili9Konstantine Chutkerashvili10Department of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, GeorgiaN. Kipshidze Central University Hospital, 0177 Tbilisi, GeorgiaDepartment of Cell Therapy and Cancer Immunotherapy, Cancer Research Centre, 0177 Tbilisi, GeorgiaDepartment of Cell Therapy and Cancer Immunotherapy, Cancer Research Centre, 0177 Tbilisi, GeorgiaDepartment of Neurosurgery, Archangel St. Michael Multi Profile Clinical Hospital, 0112 Tbilisi, GeorgiaDepartment of Neurosurgery, Ruhr University Bochum, 44801 Bochum, GermanyDepartment of Cell Therapy and Cancer Immunotherapy, Cancer Research Centre, 0177 Tbilisi, GeorgiaDepartment of Cell Therapy and Cancer Immunotherapy, Cancer Research Centre, 0177 Tbilisi, GeorgiaN. Kipshidze Central University Hospital, 0177 Tbilisi, GeorgiaDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, GeorgiaDepartment of Clinical Anatomy, Tbilisi State Medical University, 0177 Tbilisi, GeorgiaIntroduction. A total of 18 patients, with complete motor deficits and paraplegia caused by thoracic and lumbar spine trauma without muscle atrophy or psychiatric problems, were included into this study. Materials and Methods. The bone marrow was aspirated from the anterior iliac crest under local anesthesia and the mononuclear fraction was isolated by density gradient method. At least 750 million mononuclear-enriched cells, suspended in 2 mL of saline, were infused intrathecally. Results and Discussion. The study reports demonstrated improvement of motor and sensory functions of various degrees observed in 9 of the 18 (50%) cases after bone marrow stem cell transplantation. Measured by the American Spinal Injury Association (ASIA) scale, 7 (78%) out of the 9 patients observed an improvement by one grade, while two cases (22%) saw an improvement by two grades. However, there were no cases in which the condition was improved by three grades. Conclusions. Analysis of subsequent treatment results indicated that the transplantation of mononuclear-enriched autologous BMSCs is a feasible and safe technique. However, successful application of the BMSCs in the clinical practice is associated with the necessity of executing more detailed examinations to evaluate the effect of BMSCs on the patients with spinal cord injury.http://dx.doi.org/10.1155/2016/6768274 |
| spellingShingle | Zurab Kakabadze Nickolas Kipshidze Konstantine Mardaleishvili Gocha Chutkerashvili Irakli Chelishvili Albrecht Harders George Loladze Gocha Shatirishvili Nodar Kipshidze David Chakhunashvili Konstantine Chutkerashvili Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury Stem Cells International |
| title | Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury |
| title_full | Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury |
| title_fullStr | Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury |
| title_full_unstemmed | Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury |
| title_short | Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury |
| title_sort | phase 1 trial of autologous bone marrow stem cell transplantation in patients with spinal cord injury |
| url | http://dx.doi.org/10.1155/2016/6768274 |
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