A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma
Plasmablastic lymphoma (PBL) and plasmablastic plasma cell myeloma (PCM) have many overlapping characteristics. Clinical correlation can help make the distinction between the two entities. Human immunodeficiency virus- (HIV-) negative PBL is a rare disease, making the diagnosis more challenging. Whi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/2907317 |
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| author | Alaina J. Kessler Bridget K. Marcellino Scot A. Niglio Bruce E. Petersen Adriana K. Malone |
| author_facet | Alaina J. Kessler Bridget K. Marcellino Scot A. Niglio Bruce E. Petersen Adriana K. Malone |
| author_sort | Alaina J. Kessler |
| collection | DOAJ |
| description | Plasmablastic lymphoma (PBL) and plasmablastic plasma cell myeloma (PCM) have many overlapping characteristics. Clinical correlation can help make the distinction between the two entities. Human immunodeficiency virus- (HIV-) negative PBL is a rare disease, making the diagnosis more challenging. While there is no standard of care for PBL, current recommendations include dose-adjusted EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone), with or without bortezomib. We report an aggressive case of HIV-negative plasmablastic lymphoma and discuss the challenge in establishing a diagnosis. We review the literature regarding this disease and current recommendations for treatment. |
| format | Article |
| id | doaj-art-6d612f24a9914276a4153ed7ded0673f |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6d612f24a9914276a4153ed7ded0673f2025-02-03T06:44:49ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/29073172907317A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic DilemmaAlaina J. Kessler0Bridget K. Marcellino1Scot A. Niglio2Bruce E. Petersen3Adriana K. Malone4Department of Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USATisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USATisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USATisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAPlasmablastic lymphoma (PBL) and plasmablastic plasma cell myeloma (PCM) have many overlapping characteristics. Clinical correlation can help make the distinction between the two entities. Human immunodeficiency virus- (HIV-) negative PBL is a rare disease, making the diagnosis more challenging. While there is no standard of care for PBL, current recommendations include dose-adjusted EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone), with or without bortezomib. We report an aggressive case of HIV-negative plasmablastic lymphoma and discuss the challenge in establishing a diagnosis. We review the literature regarding this disease and current recommendations for treatment.http://dx.doi.org/10.1155/2019/2907317 |
| spellingShingle | Alaina J. Kessler Bridget K. Marcellino Scot A. Niglio Bruce E. Petersen Adriana K. Malone A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma Case Reports in Hematology |
| title | A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma |
| title_full | A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma |
| title_fullStr | A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma |
| title_full_unstemmed | A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma |
| title_short | A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma |
| title_sort | rare presentation of hiv negative plasmablastic lymphoma a diagnostic dilemma |
| url | http://dx.doi.org/10.1155/2019/2907317 |
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