HOXB8 mediates resistance to cetuximab in colorectal cancer cells through activation of the STAT3 pathway
Abstract Homeobox B8 (HOXB8) belongs to the HOX family and was essential to the development of colorectal carcinoma. Among the prevalent monoclonal antibodies for treating RAS/BRAF wild-type metastatic colorectal cancer (mCRC) patients, cetuximab stands out, but resistance to cetuximab frequently ar...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-10-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-024-01440-z |
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