Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosi...
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2025-01-01
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| Series: | Antioxidants |
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| author | Fabrizio Termite Sebastiano Archilei Francesca D’Ambrosio Lucrezia Petrucci Nicholas Viceconti Roberta Iaccarino Antonio Liguori Antonio Gasbarrini Luca Miele |
| author_facet | Fabrizio Termite Sebastiano Archilei Francesca D’Ambrosio Lucrezia Petrucci Nicholas Viceconti Roberta Iaccarino Antonio Liguori Antonio Gasbarrini Luca Miele |
| author_sort | Fabrizio Termite |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation and progression remain incompletely understood. Oxidative stress and lipid peroxidation are pivotal in the “multiple parallel hit model”, contributing to hepatic cell death and tissue damage. Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. Moreover, various exogenous factors impact gut microbiota and its involvement in MASLD-related oxidative stress, such as air pollution, physical activity, cigarette smoke, alcohol, and dietary patterns. This manuscript aims to provide a state-of-the-art overview focused on the intricate interplay between gut microbiota, lipid peroxidation, and MASLD pathogenesis, offering insights into potential strategies to prevent disease progression and its associated complications. |
| format | Article |
| id | doaj-art-6d51b42e114c4970837c6c1f9733bfc9 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Antioxidants |
| spelling | doaj-art-6d51b42e114c4970837c6c1f9733bfc92025-01-24T13:19:20ZengMDPI AGAntioxidants2076-39212025-01-011415610.3390/antiox14010056Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLDFabrizio Termite0Sebastiano Archilei1Francesca D’Ambrosio2Lucrezia Petrucci3Nicholas Viceconti4Roberta Iaccarino5Antonio Liguori6Antonio Gasbarrini7Luca Miele8CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyCEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, ItalyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation and progression remain incompletely understood. Oxidative stress and lipid peroxidation are pivotal in the “multiple parallel hit model”, contributing to hepatic cell death and tissue damage. Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. Moreover, various exogenous factors impact gut microbiota and its involvement in MASLD-related oxidative stress, such as air pollution, physical activity, cigarette smoke, alcohol, and dietary patterns. This manuscript aims to provide a state-of-the-art overview focused on the intricate interplay between gut microbiota, lipid peroxidation, and MASLD pathogenesis, offering insights into potential strategies to prevent disease progression and its associated complications.https://www.mdpi.com/2076-3921/14/1/56metabolic dysfunction-associated steatotic liver diseasegut microbiotaoxidative stresslipid peroxidationintestinal permeabilityfarnesoid X receptor |
| spellingShingle | Fabrizio Termite Sebastiano Archilei Francesca D’Ambrosio Lucrezia Petrucci Nicholas Viceconti Roberta Iaccarino Antonio Liguori Antonio Gasbarrini Luca Miele Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD Antioxidants metabolic dysfunction-associated steatotic liver disease gut microbiota oxidative stress lipid peroxidation intestinal permeability farnesoid X receptor |
| title | Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD |
| title_full | Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD |
| title_fullStr | Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD |
| title_full_unstemmed | Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD |
| title_short | Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD |
| title_sort | gut microbiota at the crossroad of hepatic oxidative stress and masld |
| topic | metabolic dysfunction-associated steatotic liver disease gut microbiota oxidative stress lipid peroxidation intestinal permeability farnesoid X receptor |
| url | https://www.mdpi.com/2076-3921/14/1/56 |
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