New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study
Purpose. To evaluate risk factors associated with keratoconus in a monocentric cross-sectional case-control study. Methods. This observational study occurred from June 2019 to February 2021 in a university hospital (France). The case group consisted of 195 patients with keratoconus in at least one e...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/6605771 |
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| author | Eloi Debourdeau Gabriel Planells Chloe Chamard David Touboul Max Villain Pascal Demoly Fanny Babeau Pierre Fournie Vincent Daien |
| author_facet | Eloi Debourdeau Gabriel Planells Chloe Chamard David Touboul Max Villain Pascal Demoly Fanny Babeau Pierre Fournie Vincent Daien |
| author_sort | Eloi Debourdeau |
| collection | DOAJ |
| description | Purpose. To evaluate risk factors associated with keratoconus in a monocentric cross-sectional case-control study. Methods. This observational study occurred from June 2019 to February 2021 in a university hospital (France). The case group consisted of 195 patients with keratoconus in at least one eye who were followed up by a corneal specialist. The control group consisted of 195 patients without any evidence of keratoconus on slit-lamp examination and corneal topography, who were matched 1 : 1 to controls by age and sex. Data were collected by a self-completed paper questionnaire before the consultation, and a multivariate logistic regression was performed. Results. Multivariate analysis revealed significant associations of keratoconus with family history (odds ratio [OR] = 22.2, p<0.001), rubbing eyes (OR = 10.9, p<0.001), allergy (any kind) (OR = 3.80, p<0.001), smoking exposure (OR = 2.08, p=0.017), and dry eyes (OR = 1.77, p=0.045f). The worst eye was associated with the more rubbed eye (p<0.001) and the more pressed eye during the night according to sleeping position (p<0.041). Conclusion. This study confirmed the association between keratoconus and eye rubbing, family history, and allergy. It highlighted the role of pressure on the eyes during sleep. Other less known risk factors such as dry eyes and smoking exposure should be explored in future studies. |
| format | Article |
| id | doaj-art-6d4e901502ce42b2806dd25384224f46 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-6d4e901502ce42b2806dd25384224f462025-02-03T05:57:29ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/6605771New Keratoconus Risk Factors: A Cross-Sectional Case—Control StudyEloi Debourdeau0Gabriel Planells1Chloe Chamard2David Touboul3Max Villain4Pascal Demoly5Fanny Babeau6Pierre Fournie7Vincent Daien8Department of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyNational Center of KeratoconusDepartment of OphthalmologyCentre Hospitalier UniversitaireDepartment of OphthalmologyNational Center of KeratoconusDepartment of OphthalmologyPurpose. To evaluate risk factors associated with keratoconus in a monocentric cross-sectional case-control study. Methods. This observational study occurred from June 2019 to February 2021 in a university hospital (France). The case group consisted of 195 patients with keratoconus in at least one eye who were followed up by a corneal specialist. The control group consisted of 195 patients without any evidence of keratoconus on slit-lamp examination and corneal topography, who were matched 1 : 1 to controls by age and sex. Data were collected by a self-completed paper questionnaire before the consultation, and a multivariate logistic regression was performed. Results. Multivariate analysis revealed significant associations of keratoconus with family history (odds ratio [OR] = 22.2, p<0.001), rubbing eyes (OR = 10.9, p<0.001), allergy (any kind) (OR = 3.80, p<0.001), smoking exposure (OR = 2.08, p=0.017), and dry eyes (OR = 1.77, p=0.045f). The worst eye was associated with the more rubbed eye (p<0.001) and the more pressed eye during the night according to sleeping position (p<0.041). Conclusion. This study confirmed the association between keratoconus and eye rubbing, family history, and allergy. It highlighted the role of pressure on the eyes during sleep. Other less known risk factors such as dry eyes and smoking exposure should be explored in future studies.http://dx.doi.org/10.1155/2022/6605771 |
| spellingShingle | Eloi Debourdeau Gabriel Planells Chloe Chamard David Touboul Max Villain Pascal Demoly Fanny Babeau Pierre Fournie Vincent Daien New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study Journal of Ophthalmology |
| title | New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study |
| title_full | New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study |
| title_fullStr | New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study |
| title_full_unstemmed | New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study |
| title_short | New Keratoconus Risk Factors: A Cross-Sectional Case—Control Study |
| title_sort | new keratoconus risk factors a cross sectional case control study |
| url | http://dx.doi.org/10.1155/2022/6605771 |
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