Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation
Purpose. To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. Patients and Methods: 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not cont...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/6537413 |
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| author | Islam Mahmoud Hamdi |
| author_facet | Islam Mahmoud Hamdi |
| author_sort | Islam Mahmoud Hamdi |
| collection | DOAJ |
| description | Purpose. To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. Patients and Methods: 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. They were then examined weekly for 1 month. An additional examination was made after 2 months. Visual acuity (Log MAR) was assessed at every visit. Rate of healing (% of covered area) and subjective sensation of discomfort (scale 0–5) were assessed in the 1st 3 visits. Residual manifest cylinder (D) (as a parameter of corneal irregularity) and corneal clarity (epithelial and stromal haze) were assessed from week 1 to month 2. Results. During the first 3 days, both groups showed statistically nonsignificant (P>0.05) results. From week 1 to month 2, eyes receiving D-panthenol showed better vision and less residual cylinder (P<0.05) at week 1. For all other parameters, and at different examinations, both groups showed a statistically nonsignificant (P>0.05) difference. Still, eyes receiving D-panthenol showed better values at the majority of the parameters tested. Conclusion. D-Panthenol effect on corneal epithelial regeneration is of minimal clinical relevance. A different dosage and a larger sample of patients might reveal a statistical relevance. This trial is registered with https://doi.org/10.1186/ISRCTN81441126. |
| format | Article |
| id | doaj-art-6d4d23e1d5a54854aea2d5777e1c5046 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-6d4d23e1d5a54854aea2d5777e1c50462025-02-03T07:24:22ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/65374136537413Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser AblationIslam Mahmoud Hamdi0Associate Professor, Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose. To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. Patients and Methods: 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. They were then examined weekly for 1 month. An additional examination was made after 2 months. Visual acuity (Log MAR) was assessed at every visit. Rate of healing (% of covered area) and subjective sensation of discomfort (scale 0–5) were assessed in the 1st 3 visits. Residual manifest cylinder (D) (as a parameter of corneal irregularity) and corneal clarity (epithelial and stromal haze) were assessed from week 1 to month 2. Results. During the first 3 days, both groups showed statistically nonsignificant (P>0.05) results. From week 1 to month 2, eyes receiving D-panthenol showed better vision and less residual cylinder (P<0.05) at week 1. For all other parameters, and at different examinations, both groups showed a statistically nonsignificant (P>0.05) difference. Still, eyes receiving D-panthenol showed better values at the majority of the parameters tested. Conclusion. D-Panthenol effect on corneal epithelial regeneration is of minimal clinical relevance. A different dosage and a larger sample of patients might reveal a statistical relevance. This trial is registered with https://doi.org/10.1186/ISRCTN81441126.http://dx.doi.org/10.1155/2018/6537413 |
| spellingShingle | Islam Mahmoud Hamdi Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation Journal of Ophthalmology |
| title | Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation |
| title_full | Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation |
| title_fullStr | Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation |
| title_full_unstemmed | Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation |
| title_short | Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation |
| title_sort | effect of d panthenol on corneal epithelial healing after surface laser ablation |
| url | http://dx.doi.org/10.1155/2018/6537413 |
| work_keys_str_mv | AT islammahmoudhamdi effectofdpanthenoloncornealepithelialhealingaftersurfacelaserablation |