Dysregulated Functions of Lung Macrophage Populations in COPD
Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease’s progression, and in particular, lung macrophages exploit their prevalence and strategic loca...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2349045 |
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| author | Theodore S. Kapellos Kevin Bassler Anna C. Aschenbrenner Wataru Fujii Joachim L. Schultze |
| author_facet | Theodore S. Kapellos Kevin Bassler Anna C. Aschenbrenner Wataru Fujii Joachim L. Schultze |
| author_sort | Theodore S. Kapellos |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease’s progression, and in particular, lung macrophages exploit their prevalence and strategic localisation to orchestrate immune responses. To date, alveolar and interstitial resident macrophages as well as blood monocytes have been described in the lungs of patients with COPD contributing to disease pathology by changes in their functional repertoire. In this review, we summarise recent evidence from human studies and work with animal models of COPD with regard to altered functions of each of these myeloid cell populations. We primarily focus on the dysregulated capacity of alveolar macrophages to secrete proinflammatory mediators and proteases, induce oxidative stress, engulf microbes and apoptotic cells, and express surface and intracellular markers in patients with COPD. In addition, we discuss the differences in the responses between alveolar macrophages and interstitial macrophages/monocytes in the disease and propose how the field should advance to better understand the implications of lung macrophage functions in COPD. |
| format | Article |
| id | doaj-art-6d497e605f5147ef8ccc44c60f07be38 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6d497e605f5147ef8ccc44c60f07be382025-02-03T06:13:06ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/23490452349045Dysregulated Functions of Lung Macrophage Populations in COPDTheodore S. Kapellos0Kevin Bassler1Anna C. Aschenbrenner2Wataru Fujii3Joachim L. Schultze4Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), Carl-Troll-Str. 31, 53115 Bonn, GermanyGenomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), Carl-Troll-Str. 31, 53115 Bonn, GermanyGenomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), Carl-Troll-Str. 31, 53115 Bonn, GermanyGenomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), Carl-Troll-Str. 31, 53115 Bonn, GermanyGenomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), Carl-Troll-Str. 31, 53115 Bonn, GermanyChronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease’s progression, and in particular, lung macrophages exploit their prevalence and strategic localisation to orchestrate immune responses. To date, alveolar and interstitial resident macrophages as well as blood monocytes have been described in the lungs of patients with COPD contributing to disease pathology by changes in their functional repertoire. In this review, we summarise recent evidence from human studies and work with animal models of COPD with regard to altered functions of each of these myeloid cell populations. We primarily focus on the dysregulated capacity of alveolar macrophages to secrete proinflammatory mediators and proteases, induce oxidative stress, engulf microbes and apoptotic cells, and express surface and intracellular markers in patients with COPD. In addition, we discuss the differences in the responses between alveolar macrophages and interstitial macrophages/monocytes in the disease and propose how the field should advance to better understand the implications of lung macrophage functions in COPD.http://dx.doi.org/10.1155/2018/2349045 |
| spellingShingle | Theodore S. Kapellos Kevin Bassler Anna C. Aschenbrenner Wataru Fujii Joachim L. Schultze Dysregulated Functions of Lung Macrophage Populations in COPD Journal of Immunology Research |
| title | Dysregulated Functions of Lung Macrophage Populations in COPD |
| title_full | Dysregulated Functions of Lung Macrophage Populations in COPD |
| title_fullStr | Dysregulated Functions of Lung Macrophage Populations in COPD |
| title_full_unstemmed | Dysregulated Functions of Lung Macrophage Populations in COPD |
| title_short | Dysregulated Functions of Lung Macrophage Populations in COPD |
| title_sort | dysregulated functions of lung macrophage populations in copd |
| url | http://dx.doi.org/10.1155/2018/2349045 |
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