LC/MS/MS Analysis of N-Terminal Protein Adducts with Improved Sensitivity: A Comparison of Selected Edman Isothiocyanate Reagents

LC/MS/MS Analysis of N-Terminal Protein Adducts with Improved Sensitivity: A Comparison of Selected Edman Isothiocyanate Reagents

This study provides a basis for a new and straightforward method for LC/MS/MS-based screening of N-terminal protein adducts. This procedure is denoted the “FIRE procedure” as fluorescein isothiocyanate (FITC) gave superior sensitivity by LC/MS/MS when measuring adducts (R) of electrophilic compound...

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Bibliographic Details
Main Authors: Per Rydberg, Hans von Stedingk, Jörgen Magnér, Jonas Björklund
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2009/153472
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