HIV Tat as a latency reversing agent: turning the tables on viral persistence

HIV Tat as a latency reversing agent: turning the tables on viral persistence

The ‘shock and kill’ approach to an HIV cure involves the use of latency reversing agents (LRAs) to reactivate latent HIV, with the aim to induce death of infected cells through virus induced cytolysis or immune mediated clearance. Most LRAs tested to date have been unable to overcome the blocks to...

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Bibliographic Details
Main Authors: Bridget M. Fisher, Paula M. Cevaal, Michael Roche, Sharon R. Lewin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
HIV
latency
Tat
latency reversal agent
HIV cure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571151/full
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