A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice

A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice

BackgroundPeptides were designed to induce immune tolerance to the major antigen associated with house dust mite (HDM) allergy, Der p 1. HDM is commonly associated with allergic responses in allergic rhinitis and asthma, with Der p 1 specific T-cells implicated in ongoing disease. Tolerogenic peptid...

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Bibliographic Details
Main Authors: Heather B. Streeter, Lora G. Lucas, Robert M. West, Mamidipudi T. Krishna, David C. Wraith
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
allergy
Der p 1
epitope
immunotherapy
tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569283/full
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