Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value
Objective Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren’s disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significan...
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BMJ Publishing Group
2025-02-01
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| Online Access: | https://rmdopen.bmj.com/content/11/1/e005212.full |
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| author | Xavier Mariette Gaetane Nocturne Pascale Chretien Claire Goulvestre Paul Cioni Eric Ballot Dounia Khelifi-Touhami |
| author_facet | Xavier Mariette Gaetane Nocturne Pascale Chretien Claire Goulvestre Paul Cioni Eric Ballot Dounia Khelifi-Touhami |
| author_sort | Xavier Mariette |
| collection | DOAJ |
| description | Objective Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren’s disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.Methods We conducted a retrospective study across three hospitals of the Assistance Publique—Hôpitaux de Paris. Patients with anti-SS-B positivity were identified using ELISA, addressable laser beam immunoassay (ALBIA) and immunodot assays. They were retained if anti-SS-B was positive in two techniques and anti-SS-A was absent. Clinical, biological and immunological data were extracted and presented in a descriptive analysis.Results A total of 80 540 requests for anti-SS-B antibody testing were carried out over a period of 7.9 years. Anti-SS-B positivity was found in 1693 patients. Among them, 335 (19.8%) patients had isolated anti-SS-B in ELISA/ALBIA. Immunodot was performed in 186 of them and confirmed anti-SS-B positivity in 61 patients (3.6% of anti-SS-B positivity). 24 patients (39.3%) presented with a history of various autoimmune or autoinflammatory diseases and only 6 were diagnosed with a new connective tissue disease. After a median follow-up of 26 months, only two new diagnoses were made.Conclusion Anti-SS-B without anti-SS-A is exceedingly rare when accurately identified by a rigorous immunological approach. The initial anti-SS-B positivity does not correlate with a specific condition, both at the time of initial identification and after a 26-month follow-up period. This supports the fact that isolated anti-SS-B has no diagnostic or prognostic value. |
| format | Article |
| id | doaj-art-6cf8658285254ba2a03da5ac69e72088 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-6cf8658285254ba2a03da5ac69e720882025-02-05T03:35:11ZengBMJ Publishing GroupRMD Open2056-59332025-02-0111110.1136/rmdopen-2024-005212Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic valueXavier Mariette0Gaetane Nocturne1Pascale Chretien2Claire Goulvestre3Paul Cioni4Eric Ballot5Dounia Khelifi-Touhami6Rhumatologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, FranceRhumatologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, FranceLaboratoire d`Immunologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, FranceLaboratoire d`Immunologie, Hôpital Cochin, Paris, Île-de-France, FranceRhumatologie, CHU Bicêtre, Le Kremlin-Bicetre, Île-de-France, FranceLaboratoire d`Immunologie, Hôpital Saint-Antoine, Paris, Île-de-France, FranceLaboratoire d`Immunologie, Hôpital Saint-Antoine, Paris, Île-de-France, FranceObjective Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren’s disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.Methods We conducted a retrospective study across three hospitals of the Assistance Publique—Hôpitaux de Paris. Patients with anti-SS-B positivity were identified using ELISA, addressable laser beam immunoassay (ALBIA) and immunodot assays. They were retained if anti-SS-B was positive in two techniques and anti-SS-A was absent. Clinical, biological and immunological data were extracted and presented in a descriptive analysis.Results A total of 80 540 requests for anti-SS-B antibody testing were carried out over a period of 7.9 years. Anti-SS-B positivity was found in 1693 patients. Among them, 335 (19.8%) patients had isolated anti-SS-B in ELISA/ALBIA. Immunodot was performed in 186 of them and confirmed anti-SS-B positivity in 61 patients (3.6% of anti-SS-B positivity). 24 patients (39.3%) presented with a history of various autoimmune or autoinflammatory diseases and only 6 were diagnosed with a new connective tissue disease. After a median follow-up of 26 months, only two new diagnoses were made.Conclusion Anti-SS-B without anti-SS-A is exceedingly rare when accurately identified by a rigorous immunological approach. The initial anti-SS-B positivity does not correlate with a specific condition, both at the time of initial identification and after a 26-month follow-up period. This supports the fact that isolated anti-SS-B has no diagnostic or prognostic value.https://rmdopen.bmj.com/content/11/1/e005212.full |
| spellingShingle | Xavier Mariette Gaetane Nocturne Pascale Chretien Claire Goulvestre Paul Cioni Eric Ballot Dounia Khelifi-Touhami Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value RMD Open |
| title | Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value |
| title_full | Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value |
| title_fullStr | Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value |
| title_full_unstemmed | Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value |
| title_short | Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value |
| title_sort | isolated anti ss b la antibodies rare occurrence and lack of diagnostic value |
| url | https://rmdopen.bmj.com/content/11/1/e005212.full |
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