Clinical insights on paratuberculosis in Arabian camels (Camelus dromedarius): A review
Paratuberculosis (PTB) is a long-standing granulomatous infectious disease of both domesticated and wild ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP). This review emphasizes the clinical, hematobiochemical, sonographic and pathologic findings as well as therapeutic an...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2025-01-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=209936 |
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| Summary: | Paratuberculosis (PTB) is a long-standing granulomatous infectious disease of both domesticated and wild ruminants. It is caused by Mycobacterium avium subsp. paratuberculosis (MAP). This review emphasizes the clinical, hematobiochemical, sonographic and pathologic findings as well as therapeutic and control measures in dromedary camels infected with PTB. The clinical signs include intermittent and/or chronic diarrhea, decreased milk yield, emaciation, submandibular edema, dehydration, irregular and weak rumen contractions and abdominal pain. Hematological changes include leukocytosis, neutrophilia and decreased erythrocytes, hematocrit percent and hemoglobin concentration. Biochemical alterations included hypoalbuminemia, hypoproteinemia, hyperglobulinemia, hypomagnesemia, hypoglycemia and increased alanine aminotransferase and aspartate aminotransferase activity and increased concentration of magnesium and calcium. Sonographically, the intestinal wall is either mildly, moderately or severely thickened along with mesenteric lymph nodes (LN) enlargement. The LN capsule is either anechoic or echoic and the contents are either echogenic, anechoic or heterogenous. Other sonographic findings include bright hepatic parenchyma, aggregation of echogenic materials separated with fluids among the intestines and pleural and pericardial effusions. The typical pathological lesions are corrugation of the small intestinal mucosa especially that of the ileum, and the colonic mucosa are folded. Mesenteric and ileocecal LNs are edematous, congested and granular. Other necropsy findings include fatty liver, and peritoneal, pericardial and pleural effusions. Histologically, proliferative enteritis and lepromatous granulomas are detected. Clusters of acid-fast bacilli are usually found in the intestinal mucosa and lamina propria. Accurate diagnosis of PTB depends on culture and identification of the causative organism MAP from tissue or feces. Herd screening is also performed through complement fixation, agar gel immunodiffusion, competitive enzyme linked immunosorbent assay, Ziehl-Neelsen staining of tissue or feces, histologic pattern of a granulomatous reaction, DNA probes and polymerase chain reaction. A trial for treatment of PTB in dromedary camels was carried out through IM injection of rifampin and streptomycin for 10 weeks. The diarrhea resolved within one week of treatment, and MAP disappeared from rectal scraping 5-9 weeks after treatment. In conclusion, early detection and eradication procedures of PTB should be more implemented for the control and prevention PTB in dromedary camels. More research should be directed towards vaccination program in those species. [Open Vet J 2025; 15(1.000): 8-17] |
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| ISSN: | 2226-4485 2218-6050 |