Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study
Abstract It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little is known about the relative outcomes in patients with COVID-19 neurological or psychiatric complications. We condu...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80833-0 |
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| author | Rajish S. K. Shil Adam Seed Nkongho Egbe Franklyn Brendan F. Sargent Greta K. Wood Yun Huang Katherine C. Dodd James B. Lilleker Thomas A. Pollak Sylviane Defres Thomas M. Jenkins Nicholas W. S. Davies David A. Cousins Michael S. Zandi Thomas A. Jackson Laura A. Benjamin Ava Easton Tom Solomon John R. Bradley Patrick F. Chinnery Craig J. Smith Timothy R. Nicholson Alan Carson Rhys H. Thomas Mark Alexander Ellul Nicholas W. Wood Gerome Breen Benedict Daniel Michael the COVID-CNS Study Group |
| author_facet | Rajish S. K. Shil Adam Seed Nkongho Egbe Franklyn Brendan F. Sargent Greta K. Wood Yun Huang Katherine C. Dodd James B. Lilleker Thomas A. Pollak Sylviane Defres Thomas M. Jenkins Nicholas W. S. Davies David A. Cousins Michael S. Zandi Thomas A. Jackson Laura A. Benjamin Ava Easton Tom Solomon John R. Bradley Patrick F. Chinnery Craig J. Smith Timothy R. Nicholson Alan Carson Rhys H. Thomas Mark Alexander Ellul Nicholas W. Wood Gerome Breen Benedict Daniel Michael the COVID-CNS Study Group |
| author_sort | Rajish S. K. Shil |
| collection | DOAJ |
| description | Abstract It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little is known about the relative outcomes in patients with COVID-19 neurological or psychiatric complications. We conducted a UK multicentre case–control study of patients hospitalised with COVID-19 (controls) and those who developed COVID-19 associated acute neurological or psychiatric complications (cases). Among the 651 patients, [362 (55%) cases and 289 (45%) controls], a higher proportion of cases had impairment in ADLs (199 [68.9%] vs 101 [51.8%], OR 2.06, p < 0.0002) and reported symptoms impacting employment (159 [58.2%] vs 69 [35.6%] OR 2.53, p < 0.0001). There was no significant difference in the proportion with depression or anxiety between case and control groups overall. For cases, impairment of ADLs was associated with increased risk in female sex, age > 50 years and hypertension (OR 5.43, p < 0.003, 3.11, p = 0.02, 3.66, p = 0.04). Those receiving either statins or angiotensin converting enzyme (ACE) inhibitors had a lower risk of impairment in ADLs (OR 0.09, p = 0.0006, 0.17, p = 0.03). Patients with neurological or psychiatric complications of COVID-19 had worse functional outcomes than those with respiratory COVID-19 alone in terms of ADLs and employment. Female sex, age > 50 years, and hypertension were associated with worse outcomes, and statins or ACE inhibitors with better outcomes. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-6cd78823787e4331b4d165541a6a48512025-02-02T12:21:40ZengNature PortfolioScientific Reports2045-23222025-01-0115111410.1038/s41598-024-80833-0Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control studyRajish S. K. Shil0Adam Seed1Nkongho Egbe Franklyn2Brendan F. Sargent3Greta K. Wood4Yun Huang5Katherine C. Dodd6James B. Lilleker7Thomas A. Pollak8Sylviane Defres9Thomas M. Jenkins10Nicholas W. S. Davies11David A. Cousins12Michael S. Zandi13Thomas A. Jackson14Laura A. Benjamin15Ava Easton16Tom Solomon17John R. Bradley18Patrick F. Chinnery19Craig J. Smith20Timothy R. Nicholson21Alan Carson22Rhys H. Thomas23Mark Alexander Ellul24Nicholas W. Wood25Gerome Breen26Benedict Daniel Michael27the COVID-CNS Study GroupClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolLiverpool University Hospitals NHS Foundation TrustClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolManchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science CentreManchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science CentreDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolCurtin UniversityDepartment of Neurology, Charing Cross HospitalTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityUCL Queen Square Institute of Neurology, University College LondonMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of BirminghamInstitute of Infection, Veterinary and Ecological Sciences, National Institute for Health and Care Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolNIHR BioResource, Cambridge University Hospitals NHS FoundationDepartment of Clinical Neurosciences, University of CambridgeManchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science CentreDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonCentre for Clinical Brain Sciences, University of EdinburghTranslational and Clinical Research, Newcastle UniversityClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolDepartment of Molecular Neuroscience, UCL Institute of NeurologyClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolClinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of LiverpoolAbstract It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little is known about the relative outcomes in patients with COVID-19 neurological or psychiatric complications. We conducted a UK multicentre case–control study of patients hospitalised with COVID-19 (controls) and those who developed COVID-19 associated acute neurological or psychiatric complications (cases). Among the 651 patients, [362 (55%) cases and 289 (45%) controls], a higher proportion of cases had impairment in ADLs (199 [68.9%] vs 101 [51.8%], OR 2.06, p < 0.0002) and reported symptoms impacting employment (159 [58.2%] vs 69 [35.6%] OR 2.53, p < 0.0001). There was no significant difference in the proportion with depression or anxiety between case and control groups overall. For cases, impairment of ADLs was associated with increased risk in female sex, age > 50 years and hypertension (OR 5.43, p < 0.003, 3.11, p = 0.02, 3.66, p = 0.04). Those receiving either statins or angiotensin converting enzyme (ACE) inhibitors had a lower risk of impairment in ADLs (OR 0.09, p = 0.0006, 0.17, p = 0.03). Patients with neurological or psychiatric complications of COVID-19 had worse functional outcomes than those with respiratory COVID-19 alone in terms of ADLs and employment. Female sex, age > 50 years, and hypertension were associated with worse outcomes, and statins or ACE inhibitors with better outcomes.https://doi.org/10.1038/s41598-024-80833-0 |
| spellingShingle | Rajish S. K. Shil Adam Seed Nkongho Egbe Franklyn Brendan F. Sargent Greta K. Wood Yun Huang Katherine C. Dodd James B. Lilleker Thomas A. Pollak Sylviane Defres Thomas M. Jenkins Nicholas W. S. Davies David A. Cousins Michael S. Zandi Thomas A. Jackson Laura A. Benjamin Ava Easton Tom Solomon John R. Bradley Patrick F. Chinnery Craig J. Smith Timothy R. Nicholson Alan Carson Rhys H. Thomas Mark Alexander Ellul Nicholas W. Wood Gerome Breen Benedict Daniel Michael the COVID-CNS Study Group Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study Scientific Reports |
| title | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study |
| title_full | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study |
| title_fullStr | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study |
| title_full_unstemmed | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study |
| title_short | Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study |
| title_sort | patients with neurological or psychiatric complications of covid 19 have worse long term functional outcomes covid cns a multicentre case control study |
| url | https://doi.org/10.1038/s41598-024-80833-0 |
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