Cross-sectional study of the distribution of cardiovascular diseases and risk factors in patients with prostate cancer with potential indications for endocrine therapy
Objective: this study aims to evaluate the prevalence of cardiovascular diseases (CVD) and associated risk factors in patients with prostate cancer (PCa) prior to initiation of endocrine therapy (ET), as a basis for reducing treatment-related complications and improving patient outcomes. Materials a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2025-08-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/1334 |
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| Summary: | Objective: this study aims to evaluate the prevalence of cardiovascular diseases (CVD) and associated risk factors in patients with prostate cancer (PCa) prior to initiation of endocrine therapy (ET), as a basis for reducing treatment-related complications and improving patient outcomes. Materials and Methods. A total of 59 newly diagnosed, treatment-naïve PCa patients with potential indications for ET were enrolled at Sechenov University Clinical Hospital No. 1 between May 2018 and July 2022. Clinical and laboratory data were collected, and cardiovascular risk was assessed using ASCVD stratification. Results. 83% of patients had at least one CVD; hypertension (79%) was the most prevalent condition. Blood pressure control was insufficient among patients at high cardiovascular risk. Dyslipidemia was present in 61%, mainly characterized by low HDL-C and elevated triglycerides. Only 19% of patients were on lipid-lowering therapy, and LDL-C target attainment was especially poor among high-risk patients. Conclusion. The high prevalence of CVD and poor control of modifiable risk factors prior to ET initiation emphasize the need for early cardiovascular risk assessment and management. A multidisciplinary care model is essential to optimize treatment outcomes in PCa patients. |
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| ISSN: | 2226-762X 2782-1579 |