Identification of rare anti-f alloantibody in a tertiary care center in India
A 68-year-old male known follow-up patient of nonalcoholic steatohepatitis and carcinoma stomach was admitted to hospital for further management. The patient was planned for radical gastrectomy and required two units of packed red blood cell (PRBC), due to low hemoglobin of 6.6 g/dl. The patient blo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_22_21 |
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| author | Gunjan Bhardwaj Ashish Tewari Deepak Tiwari Sanjay Vishwakarma |
| author_facet | Gunjan Bhardwaj Ashish Tewari Deepak Tiwari Sanjay Vishwakarma |
| author_sort | Gunjan Bhardwaj |
| collection | DOAJ |
| description | A 68-year-old male known follow-up patient of nonalcoholic steatohepatitis and carcinoma stomach was admitted to hospital for further management. The patient was planned for radical gastrectomy and required two units of packed red blood cell (PRBC), due to low hemoglobin of 6.6 g/dl. The patient blood grouping and antibody screening (ABS) were done. Patient ABS was positive. On antibody identification, using eleven-cell identification panel, resolve Panel A (Ortho Clinical Diagnostics, Johnson and Johnson, USA), “anti-f” alloantibody was identified in the patient sample. Select cells, from another resolve panel were used to rule out remaining antibodies. Anti-f antibody is produced due to the exposure of “f antigen.” Anti-f antibody can cause hemolytic disease of fetus and new-born and possible hemolytic transfusion reactions. At our center, we successfully transfused two units of anti-human globulin compatible and “c-negative” units, to the patient without any adverse reactions. Thus, the patient having anti-f antibody can be managed by transfusing “c-negative” or “e-negative” PRBC units or units lacking both the “c” and “e” antigens. |
| format | Article |
| id | doaj-art-6cccfef19af14779a13067a493ee434f |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-6cccfef19af14779a13067a493ee434f2025-01-20T09:40:25ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652024-01-0118113113410.4103/ajts.ajts_22_21Identification of rare anti-f alloantibody in a tertiary care center in IndiaGunjan BhardwajAshish TewariDeepak TiwariSanjay VishwakarmaA 68-year-old male known follow-up patient of nonalcoholic steatohepatitis and carcinoma stomach was admitted to hospital for further management. The patient was planned for radical gastrectomy and required two units of packed red blood cell (PRBC), due to low hemoglobin of 6.6 g/dl. The patient blood grouping and antibody screening (ABS) were done. Patient ABS was positive. On antibody identification, using eleven-cell identification panel, resolve Panel A (Ortho Clinical Diagnostics, Johnson and Johnson, USA), “anti-f” alloantibody was identified in the patient sample. Select cells, from another resolve panel were used to rule out remaining antibodies. Anti-f antibody is produced due to the exposure of “f antigen.” Anti-f antibody can cause hemolytic disease of fetus and new-born and possible hemolytic transfusion reactions. At our center, we successfully transfused two units of anti-human globulin compatible and “c-negative” units, to the patient without any adverse reactions. Thus, the patient having anti-f antibody can be managed by transfusing “c-negative” or “e-negative” PRBC units or units lacking both the “c” and “e” antigens.https://journals.lww.com/10.4103/ajts.ajts_22_21antibody identificationantibody screenanti-f antibodyc-negativee-negativef antigen |
| spellingShingle | Gunjan Bhardwaj Ashish Tewari Deepak Tiwari Sanjay Vishwakarma Identification of rare anti-f alloantibody in a tertiary care center in India Asian Journal of Transfusion Science antibody identification antibody screen anti-f antibody c-negative e-negative f antigen |
| title | Identification of rare anti-f alloantibody in a tertiary care center in India |
| title_full | Identification of rare anti-f alloantibody in a tertiary care center in India |
| title_fullStr | Identification of rare anti-f alloantibody in a tertiary care center in India |
| title_full_unstemmed | Identification of rare anti-f alloantibody in a tertiary care center in India |
| title_short | Identification of rare anti-f alloantibody in a tertiary care center in India |
| title_sort | identification of rare anti f alloantibody in a tertiary care center in india |
| topic | antibody identification antibody screen anti-f antibody c-negative e-negative f antigen |
| url | https://journals.lww.com/10.4103/ajts.ajts_22_21 |
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