Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials
Gliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogene...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/2895958 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552363226824704 |
|---|---|
| author | Tao Zeng Lei Li Yan Zhou Liang Gao |
| author_facet | Tao Zeng Lei Li Yan Zhou Liang Gao |
| author_sort | Tao Zeng |
| collection | DOAJ |
| description | Gliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogenesis and progression of GBMs with potential diagnostic and therapeutic value have been explored industriously. With the advent of high-throughput technologies, numerous long noncoding RNAs (lncRNAs) aberrantly expressed in GBMs were discovered recently, some of them probably involved in GBM initiation, malignant progression, relapse and resistant to therapy, or showing diagnostic and prognostic value. In this review, we summarized the profile of lncRNAs that has been extensively investigated in glioma research, with a focus on their regulatory mechanisms. Then, their diagnostic, prognostic, and therapeutic implications were also discussed. |
| format | Article |
| id | doaj-art-6cc3ad328ac8459fb8bef048ce79a192 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-6cc3ad328ac8459fb8bef048ce79a1922025-02-03T05:58:52ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/28959582895958Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical PotentialsTao Zeng0Lei Li1Yan Zhou2Liang Gao3Department of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, ChinaDepartment of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, ChinaMedical Research Institute, College of Life Sciences, Wuhan University, Wuhan 430071, ChinaDepartment of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, ChinaGliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogenesis and progression of GBMs with potential diagnostic and therapeutic value have been explored industriously. With the advent of high-throughput technologies, numerous long noncoding RNAs (lncRNAs) aberrantly expressed in GBMs were discovered recently, some of them probably involved in GBM initiation, malignant progression, relapse and resistant to therapy, or showing diagnostic and prognostic value. In this review, we summarized the profile of lncRNAs that has been extensively investigated in glioma research, with a focus on their regulatory mechanisms. Then, their diagnostic, prognostic, and therapeutic implications were also discussed.http://dx.doi.org/10.1155/2018/2895958 |
| spellingShingle | Tao Zeng Lei Li Yan Zhou Liang Gao Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials International Journal of Genomics |
| title | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
| title_full | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
| title_fullStr | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
| title_full_unstemmed | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
| title_short | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
| title_sort | exploring long noncoding rnas in glioblastoma regulatory mechanisms and clinical potentials |
| url | http://dx.doi.org/10.1155/2018/2895958 |
| work_keys_str_mv | AT taozeng exploringlongnoncodingrnasinglioblastomaregulatorymechanismsandclinicalpotentials AT leili exploringlongnoncodingrnasinglioblastomaregulatorymechanismsandclinicalpotentials AT yanzhou exploringlongnoncodingrnasinglioblastomaregulatorymechanismsandclinicalpotentials AT lianggao exploringlongnoncodingrnasinglioblastomaregulatorymechanismsandclinicalpotentials |