Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer
This paper introduced a homemade high-performance proton transfer reaction time-of-fight mass spectrometer (PTR-TOF MS), which can be used for real-time online analysis and monitoring of complex organic gas mixtures. Proton transfer reaction ionization is one of the typical methods of “soft” ionizat...
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| Format: | Article |
| Language: | English |
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Editorial Board of Journal of Chinese Mass Spectrometry Society
2025-01-01
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| Series: | Zhipu Xuebao |
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| Online Access: | https://zpxb.xml-journal.net/article/doi/10.7538/zpxb.2024.0039 |
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| author | Chun-guang XIE Ji-yang ZHANG Tong YANG Yu-liang HUANG Shu-guang XIE Hui ZHU Jing-xuan SUN Ping CHENG |
| author_facet | Chun-guang XIE Ji-yang ZHANG Tong YANG Yu-liang HUANG Shu-guang XIE Hui ZHU Jing-xuan SUN Ping CHENG |
| author_sort | Chun-guang XIE |
| collection | DOAJ |
| description | This paper introduced a homemade high-performance proton transfer reaction time-of-fight mass spectrometer (PTR-TOF MS), which can be used for real-time online analysis and monitoring of complex organic gas mixtures. Proton transfer reaction ionization is one of the typical methods of “soft” ionization techniques, which generally takes water and hydronium ions as parent ions, and the objects which have higher proton affinity than water can be ionized. By integrating an orthogonal-injection reflectron time-of-flight mass analyzer and a micro-channel plate detector, the instrument’s resolution and sensitivity are significantly enhanced，with the characteristics of high sensitivity, a wide mass detection range, a low detection limit, a wide linear range and little sample pretreatment. The system is mainly composed of hollow cathode discharge ion source, proton transfer reaction tube, high efficiency ion transport region and high-performance time-of-flight mass analyzer. To reduce ion loss during transmission, improve system performance and ensure the stability of vacuum at all levels, the system adopts a four-stages of differential vacuum design, with the first stage being the proton transfer reaction tube, the second stage being the radio frequency quadrupole ion transport region, the third stage being the direct current quadrupole ion transport region, and the fourth stage being the time-of-flight mass analyzer. Based on the proton affinity of the reaction reagent ions, the system can analyze the majority of VOCs while excluding interference from air components. Experimental tests showed that the system’s resolution (full width half maximum, FWHM) is better than 2 069 (for toluene), with the detection limit of 0.36 μg/m3, a linear range of 4 orders of magnitude, and a linear correlation coefficient (R2) of 0.991. The development of this system provides a new method for online rapid analysis of VOCs in environmental monitoring, industrial processes, and biomedicine, accelerating the technical development of PTR-TOFMS domestically and narrowing the gap with the international advanced level. |
| format | Article |
| id | doaj-art-6cbfce6dd9d742469d19f0afc5ed3c2c |
| institution | Kabale University |
| issn | 1004-2997 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Editorial Board of Journal of Chinese Mass Spectrometry Society |
| record_format | Article |
| series | Zhipu Xuebao |
| spelling | doaj-art-6cbfce6dd9d742469d19f0afc5ed3c2c2025-01-22T02:33:54ZengEditorial Board of Journal of Chinese Mass Spectrometry SocietyZhipu Xuebao1004-29972025-01-01461788710.7538/zpxb.2024.00392024-039-b17Development of High-performance Proton Transfer Reaction Time-of-Flight Mass SpectrometerChun-guang XIE0Ji-yang ZHANG1Tong YANG2Yu-liang HUANG3Shu-guang XIE4Hui ZHU5Jing-xuan SUN6Ping CHENG7Shanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaShanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, ChinaSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, ChinaShanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaShanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaShanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaShanghai Haishan Intelligent Instrument Co., Ltd., Shanghai 200444, ChinaThis paper introduced a homemade high-performance proton transfer reaction time-of-fight mass spectrometer (PTR-TOF MS), which can be used for real-time online analysis and monitoring of complex organic gas mixtures. Proton transfer reaction ionization is one of the typical methods of “soft” ionization techniques, which generally takes water and hydronium ions as parent ions, and the objects which have higher proton affinity than water can be ionized. By integrating an orthogonal-injection reflectron time-of-flight mass analyzer and a micro-channel plate detector, the instrument’s resolution and sensitivity are significantly enhanced，with the characteristics of high sensitivity, a wide mass detection range, a low detection limit, a wide linear range and little sample pretreatment. The system is mainly composed of hollow cathode discharge ion source, proton transfer reaction tube, high efficiency ion transport region and high-performance time-of-flight mass analyzer. To reduce ion loss during transmission, improve system performance and ensure the stability of vacuum at all levels, the system adopts a four-stages of differential vacuum design, with the first stage being the proton transfer reaction tube, the second stage being the radio frequency quadrupole ion transport region, the third stage being the direct current quadrupole ion transport region, and the fourth stage being the time-of-flight mass analyzer. Based on the proton affinity of the reaction reagent ions, the system can analyze the majority of VOCs while excluding interference from air components. Experimental tests showed that the system’s resolution (full width half maximum, FWHM) is better than 2 069 (for toluene), with the detection limit of 0.36 μg/m3, a linear range of 4 orders of magnitude, and a linear correlation coefficient (R2) of 0.991. The development of this system provides a new method for online rapid analysis of VOCs in environmental monitoring, industrial processes, and biomedicine, accelerating the technical development of PTR-TOFMS domestically and narrowing the gap with the international advanced level.https://zpxb.xml-journal.net/article/doi/10.7538/zpxb.2024.0039proton transfer reactionhollow cathode dischargetime-of-flight mass spectrometry (tof ms)volatile organic compounds (vocs) |
| spellingShingle | Chun-guang XIE Ji-yang ZHANG Tong YANG Yu-liang HUANG Shu-guang XIE Hui ZHU Jing-xuan SUN Ping CHENG Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer Zhipu Xuebao proton transfer reaction hollow cathode discharge time-of-flight mass spectrometry (tof ms) volatile organic compounds (vocs) |
| title | Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer |
| title_full | Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer |
| title_fullStr | Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer |
| title_full_unstemmed | Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer |
| title_short | Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer |
| title_sort | development of high performance proton transfer reaction time of flight mass spectrometer |
| topic | proton transfer reaction hollow cathode discharge time-of-flight mass spectrometry (tof ms) volatile organic compounds (vocs) |
| url | https://zpxb.xml-journal.net/article/doi/10.7538/zpxb.2024.0039 |
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