Endothelial-Mesenchymal Transition in Regenerative Medicine
Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneratio...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6962801 |
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| _version_ | 1832550218107715584 |
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| author | Damian Medici |
| author_facet | Damian Medici |
| author_sort | Damian Medici |
| collection | DOAJ |
| description | Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration. |
| format | Article |
| id | doaj-art-6cbb26f66ebe47ffbbc2af91f1b7f648 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6cbb26f66ebe47ffbbc2af91f1b7f6482025-02-03T06:07:26ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/69628016962801Endothelial-Mesenchymal Transition in Regenerative MedicineDamian Medici0Department of Orthopaedics, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USAEndothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.http://dx.doi.org/10.1155/2016/6962801 |
| spellingShingle | Damian Medici Endothelial-Mesenchymal Transition in Regenerative Medicine Stem Cells International |
| title | Endothelial-Mesenchymal Transition in Regenerative Medicine |
| title_full | Endothelial-Mesenchymal Transition in Regenerative Medicine |
| title_fullStr | Endothelial-Mesenchymal Transition in Regenerative Medicine |
| title_full_unstemmed | Endothelial-Mesenchymal Transition in Regenerative Medicine |
| title_short | Endothelial-Mesenchymal Transition in Regenerative Medicine |
| title_sort | endothelial mesenchymal transition in regenerative medicine |
| url | http://dx.doi.org/10.1155/2016/6962801 |
| work_keys_str_mv | AT damianmedici endothelialmesenchymaltransitioninregenerativemedicine |