Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia
In this study, hot water was used to extract Inonotus obliquus oligosaccharide. DEAE-cellulose and Sepharose G-200 were used to purify Inonotus obliquus oligosaccharide. Inonotus obliquus oligosaccharide IOP-2A was obtained. Its molecular weight Mw is about 1000 Da. The monosaccharide composition an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2021/1174452 |
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| author | Dawei Wu Yanrong Zhang Dawei Wang Tingting Liu Shanshan Zhang Chenhe Yang |
| author_facet | Dawei Wu Yanrong Zhang Dawei Wang Tingting Liu Shanshan Zhang Chenhe Yang |
| author_sort | Dawei Wu |
| collection | DOAJ |
| description | In this study, hot water was used to extract Inonotus obliquus oligosaccharide. DEAE-cellulose and Sepharose G-200 were used to purify Inonotus obliquus oligosaccharide. Inonotus obliquus oligosaccharide IOP-2A was obtained. Its molecular weight Mw is about 1000 Da. The monosaccharide composition and molar ratio were glucose : xylose : galactose : mannose = 54.1 : 13.6 : 13.2 : 6.7. In addition, it also contains a small amount of galactose, gluconic acid, rhamnose, and fucose. IOP-2A contained mainly β-glycosidic bonds. Among them, 1,4-glycosidic bonds accounted for 9.2%, and 1,6-glycosidic bonds accounted for 85.1%. Oligosaccharide macromolecules formed a layered structure. Mouse experiments showed that IOP-2A had the function of preventing hyperlipidemia. At the same time, IOP-2A had a certain protective effect on the liver and kidney. The mechanism of IOP-2A in preventing hyperlipidemia was obtained from the perspective of mouse intestinal flora. |
| format | Article |
| id | doaj-art-6cab23c898c64b8eb7a5800dbc75ce7e |
| institution | Kabale University |
| issn | 1745-4557 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-6cab23c898c64b8eb7a5800dbc75ce7e2025-02-03T01:21:46ZengWileyJournal of Food Quality1745-45572021-01-01202110.1155/2021/1174452Research of Inonotus obliquus Oligosaccharide in Prevention of HyperlipidemiaDawei Wu0Yanrong Zhang1Dawei Wang2Tingting Liu3Shanshan Zhang4Chenhe Yang5College of Food Science & EngineeringCollege of Food Science & EngineeringCollege of Food Science & EngineeringCollege of Food Science & EngineeringCollege of Food Science & EngineeringCollege of Food Science & EngineeringIn this study, hot water was used to extract Inonotus obliquus oligosaccharide. DEAE-cellulose and Sepharose G-200 were used to purify Inonotus obliquus oligosaccharide. Inonotus obliquus oligosaccharide IOP-2A was obtained. Its molecular weight Mw is about 1000 Da. The monosaccharide composition and molar ratio were glucose : xylose : galactose : mannose = 54.1 : 13.6 : 13.2 : 6.7. In addition, it also contains a small amount of galactose, gluconic acid, rhamnose, and fucose. IOP-2A contained mainly β-glycosidic bonds. Among them, 1,4-glycosidic bonds accounted for 9.2%, and 1,6-glycosidic bonds accounted for 85.1%. Oligosaccharide macromolecules formed a layered structure. Mouse experiments showed that IOP-2A had the function of preventing hyperlipidemia. At the same time, IOP-2A had a certain protective effect on the liver and kidney. The mechanism of IOP-2A in preventing hyperlipidemia was obtained from the perspective of mouse intestinal flora.http://dx.doi.org/10.1155/2021/1174452 |
| spellingShingle | Dawei Wu Yanrong Zhang Dawei Wang Tingting Liu Shanshan Zhang Chenhe Yang Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia Journal of Food Quality |
| title | Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia |
| title_full | Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia |
| title_fullStr | Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia |
| title_full_unstemmed | Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia |
| title_short | Research of Inonotus obliquus Oligosaccharide in Prevention of Hyperlipidemia |
| title_sort | research of inonotus obliquus oligosaccharide in prevention of hyperlipidemia |
| url | http://dx.doi.org/10.1155/2021/1174452 |
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