Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting
Abstract Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction. However, there is currently no agreement on the MCI criteria, leading to wide heterogeneity in the prognosis of M...
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Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-04275-y |
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| author | Simone Galati Michele Rossi Federica Del Signore Giulia Locatelli Antonio Guaita Elena Rolandi |
| author_facet | Simone Galati Michele Rossi Federica Del Signore Giulia Locatelli Antonio Guaita Elena Rolandi |
| author_sort | Simone Galati |
| collection | DOAJ |
| description | Abstract Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction. However, there is currently no agreement on the MCI criteria, leading to wide heterogeneity in the prognosis of MCI patients and high reversion rates. Our study aimed to compare the prognostic value of Conventional (Petersen/Winblad) and Neuropsychological (Jak/Bondi) criteria for the diagnosis of MCI. We directly compared the ability of each classification method to predict progression to dementia and the stability of the diagnosis over 12 years in a population-based sample of 1021 older adults without dementia. The relative impact of subjective complaints and objective impairment on clinical progression was further evaluated. Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time. Across the study period, the Neuropsychological criteria led to more consistent diagnoses (63.2% vs. 43.2%). The copresence of subjective memory complaints and objective impairment at baseline was associated with increased dementia risk within both diagnostic frameworks. These results further support the use of comprehensive neuropsychological assessment to make timely and appropriate MCI diagnoses and show the added prognostic value of subjective complaints. |
| format | Article |
| id | doaj-art-6ca690e91c874e1ca1b97d13c1aa4e28 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-6ca690e91c874e1ca1b97d13c1aa4e282025-08-20T03:04:25ZengNature PortfolioScientific Reports2045-23222025-06-0115111210.1038/s41598-025-04275-yConventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical settingSimone Galati0Michele Rossi1Federica Del Signore2Giulia Locatelli3Antonio Guaita4Elena Rolandi5Golgi Cenci FoundationGolgi Cenci FoundationGolgi Cenci FoundationGolgi Cenci FoundationGolgi Cenci FoundationGolgi Cenci FoundationAbstract Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction. However, there is currently no agreement on the MCI criteria, leading to wide heterogeneity in the prognosis of MCI patients and high reversion rates. Our study aimed to compare the prognostic value of Conventional (Petersen/Winblad) and Neuropsychological (Jak/Bondi) criteria for the diagnosis of MCI. We directly compared the ability of each classification method to predict progression to dementia and the stability of the diagnosis over 12 years in a population-based sample of 1021 older adults without dementia. The relative impact of subjective complaints and objective impairment on clinical progression was further evaluated. Baseline MCI diagnosis with the Neuropsychological and Conventional criteria was associated with a comparable risk of dementia over time. Across the study period, the Neuropsychological criteria led to more consistent diagnoses (63.2% vs. 43.2%). The copresence of subjective memory complaints and objective impairment at baseline was associated with increased dementia risk within both diagnostic frameworks. These results further support the use of comprehensive neuropsychological assessment to make timely and appropriate MCI diagnoses and show the added prognostic value of subjective complaints.https://doi.org/10.1038/s41598-025-04275-yMCI diagnosisNeuropsychological criteriaConventional criteriaStabilityProgression to dementiaSubjective Memory Impairment |
| spellingShingle | Simone Galati Michele Rossi Federica Del Signore Giulia Locatelli Antonio Guaita Elena Rolandi Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting Scientific Reports MCI diagnosis Neuropsychological criteria Conventional criteria Stability Progression to dementia Subjective Memory Impairment |
| title | Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting |
| title_full | Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting |
| title_fullStr | Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting |
| title_full_unstemmed | Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting |
| title_short | Conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non-clinical setting |
| title_sort | conventional and neuropsychological criteria for mild cognitive impairment show similar prognostic value for dementia across 12 years in a non clinical setting |
| topic | MCI diagnosis Neuropsychological criteria Conventional criteria Stability Progression to dementia Subjective Memory Impairment |
| url | https://doi.org/10.1038/s41598-025-04275-y |
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