Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/212543 |
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| _version_ | 1832567008033505280 |
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| author | Shawn Y. Ong Josephine Taverna Clint Jokerst Thomas Enzler Emad Hammode Elisa Rogowitz Myke R. Green Hani M. Babiker |
| author_facet | Shawn Y. Ong Josephine Taverna Clint Jokerst Thomas Enzler Emad Hammode Elisa Rogowitz Myke R. Green Hani M. Babiker |
| author_sort | Shawn Y. Ong |
| collection | DOAJ |
| description | Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient’s coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option. |
| format | Article |
| id | doaj-art-6ca10420f43f43e9bbd3b0287ccf3b1b |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-6ca10420f43f43e9bbd3b0287ccf3b1b2025-02-03T01:02:35ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/212543212543Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with DegarelixShawn Y. Ong0Josephine Taverna1Clint Jokerst2Thomas Enzler3Emad Hammode4Elisa Rogowitz5Myke R. Green6Hani M. Babiker7University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USAUniversity of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USADepartment of Radiology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USADepartment of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Avenue, RM 6336, Tucson, AZ 85724, USADepartment of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Avenue, RM 6336, Tucson, AZ 85724, USAScripps Health, Department of Medicine, 10666 N Torrey Pines Road, La Jolla, CA 92037, USADepartment of Pharmacy Services, University of Arizona Medical Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USAUniversity of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USADisseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient’s coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.http://dx.doi.org/10.1155/2015/212543 |
| spellingShingle | Shawn Y. Ong Josephine Taverna Clint Jokerst Thomas Enzler Emad Hammode Elisa Rogowitz Myke R. Green Hani M. Babiker Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix Case Reports in Oncological Medicine |
| title | Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix |
| title_full | Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix |
| title_fullStr | Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix |
| title_full_unstemmed | Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix |
| title_short | Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix |
| title_sort | prostate cancer associated disseminated intravascular coagulation with excessive fibrinolysis treated with degarelix |
| url | http://dx.doi.org/10.1155/2015/212543 |
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