Anaphylaxis
Abstract Anaphylaxis is an acute, potentially fatal systemic hypersensitivity reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose its early...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-024-00926-3 |
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| author | Elissa M. Abrams Waleed Alqurashi David A. Fischer Timothy K. Vander Leek Anne K. Ellis |
| author_facet | Elissa M. Abrams Waleed Alqurashi David A. Fischer Timothy K. Vander Leek Anne K. Ellis |
| author_sort | Elissa M. Abrams |
| collection | DOAJ |
| description | Abstract Anaphylaxis is an acute, potentially fatal systemic hypersensitivity reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose its early signs. Clinical manifestations vary widely, however, the most common signs are cutaneous symptoms, including urticaria and angioedema. Immediate intramuscular administration of epinephrine into the anterolateral thigh is first-line therapy, and is always safe even if the diagnosis is uncertain. The mainstays of long-term management include specialist assessment, allergen avoidance measures, and the provision of an epinephrine auto-injector with an individualized anaphylaxis emergency plan. This article provides an overview of the causes, clinical features, diagnosis, and acute as well as long-term management of anaphylaxis. |
| format | Article |
| id | doaj-art-6c856ee8e2e045eebec4fe09dfd4d376 |
| institution | OA Journals |
| issn | 1710-1492 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj-art-6c856ee8e2e045eebec4fe09dfd4d3762025-08-20T02:00:03ZengBMCAllergy, Asthma & Clinical Immunology1710-14922024-12-0120S311010.1186/s13223-024-00926-3AnaphylaxisElissa M. Abrams0Waleed Alqurashi1David A. Fischer2Timothy K. Vander Leek3Anne K. Ellis4Division of Allergy, Department of Pediatrics, University of British Columbia, BC Children’s HospitalDepartment of Pediatrics and Emergency Medicine, University of OttawaDivision of Allergy, Department of Internal Medicine, Western UniversityDepartment of Pediatrics, Faculty of Medicine & Dentistry, University of AlbertaDivision of Allergy & Immunology, Department of Medicine, Queen’s UniversityAbstract Anaphylaxis is an acute, potentially fatal systemic hypersensitivity reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose its early signs. Clinical manifestations vary widely, however, the most common signs are cutaneous symptoms, including urticaria and angioedema. Immediate intramuscular administration of epinephrine into the anterolateral thigh is first-line therapy, and is always safe even if the diagnosis is uncertain. The mainstays of long-term management include specialist assessment, allergen avoidance measures, and the provision of an epinephrine auto-injector with an individualized anaphylaxis emergency plan. This article provides an overview of the causes, clinical features, diagnosis, and acute as well as long-term management of anaphylaxis.https://doi.org/10.1186/s13223-024-00926-3AnaphylaxisDiagnosisAcute managementEpinephrineLong-term managementAnaphylaxis emergency plan |
| spellingShingle | Elissa M. Abrams Waleed Alqurashi David A. Fischer Timothy K. Vander Leek Anne K. Ellis Anaphylaxis Allergy, Asthma & Clinical Immunology Anaphylaxis Diagnosis Acute management Epinephrine Long-term management Anaphylaxis emergency plan |
| title | Anaphylaxis |
| title_full | Anaphylaxis |
| title_fullStr | Anaphylaxis |
| title_full_unstemmed | Anaphylaxis |
| title_short | Anaphylaxis |
| title_sort | anaphylaxis |
| topic | Anaphylaxis Diagnosis Acute management Epinephrine Long-term management Anaphylaxis emergency plan |
| url | https://doi.org/10.1186/s13223-024-00926-3 |
| work_keys_str_mv | AT elissamabrams anaphylaxis AT waleedalqurashi anaphylaxis AT davidafischer anaphylaxis AT timothykvanderleek anaphylaxis AT annekellis anaphylaxis |