Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease
Understanding cortical inhibition and its diverse roles remains a key challenge in neurophysiological research. Traditionally, inhibition has been recognized for controlling the stability and rhythmicity of network dynamics, or refining the spatiotemporal properties of cortical representations. In t...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1479579/full |
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| author | Yann Zerlaut Alexandra Tzilivaki Alexandra Tzilivaki Alexandra Tzilivaki |
| author_facet | Yann Zerlaut Alexandra Tzilivaki Alexandra Tzilivaki Alexandra Tzilivaki |
| author_sort | Yann Zerlaut |
| collection | DOAJ |
| description | Understanding cortical inhibition and its diverse roles remains a key challenge in neurophysiological research. Traditionally, inhibition has been recognized for controlling the stability and rhythmicity of network dynamics, or refining the spatiotemporal properties of cortical representations. In this perspective, we propose that specific types of interneurons may play a complementary role, by modulating the computational properties of neural networks. We review experimental and theoretical evidence, mainly from rodent sensory cortices, that supports this view. Additionally, we explore how dysfunctions in these interneurons may disrupt the network’s ability to switch between computational modes, impacting the flexibility of cortical processing and potentially contributing to various neurodevelopmental and psychiatric disorders. |
| format | Article |
| id | doaj-art-6c610b97d2174da1bf2148573526246f |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-6c610b97d2174da1bf2148573526246f2025-01-23T06:56:40ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011810.3389/fncel.2024.14795791479579Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for diseaseYann Zerlaut0Alexandra Tzilivaki1Alexandra Tzilivaki2Alexandra Tzilivaki3Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, FranceCharité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Neuroscience Research Center, Berlin, GermanyEinstein Center for Neurosciences, Chariteplatz, Berlin, GermanyNeuroCure Cluster of Excellence, Chariteplatz, Berlin, GermanyUnderstanding cortical inhibition and its diverse roles remains a key challenge in neurophysiological research. Traditionally, inhibition has been recognized for controlling the stability and rhythmicity of network dynamics, or refining the spatiotemporal properties of cortical representations. In this perspective, we propose that specific types of interneurons may play a complementary role, by modulating the computational properties of neural networks. We review experimental and theoretical evidence, mainly from rodent sensory cortices, that supports this view. Additionally, we explore how dysfunctions in these interneurons may disrupt the network’s ability to switch between computational modes, impacting the flexibility of cortical processing and potentially contributing to various neurodevelopmental and psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fncel.2024.1479579/fullinterneuronvasoactive intestinal peptideNDNF interneuronscortical computationcortexinhibition |
| spellingShingle | Yann Zerlaut Alexandra Tzilivaki Alexandra Tzilivaki Alexandra Tzilivaki Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease Frontiers in Cellular Neuroscience interneuron vasoactive intestinal peptide NDNF interneurons cortical computation cortex inhibition |
| title | Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease |
| title_full | Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease |
| title_fullStr | Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease |
| title_full_unstemmed | Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease |
| title_short | Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease |
| title_sort | interneuronal modulations as a functional switch for cortical computations mechanisms and implication for disease |
| topic | interneuron vasoactive intestinal peptide NDNF interneurons cortical computation cortex inhibition |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1479579/full |
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