Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ)
Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds have shown promise in addressing these challenges, regenerating bone in this region remains complex due to its irregular shape, intricate structure, and differing cellula...
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2025-01-01
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| Series: | Cells |
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| author | Judit Bovari-Biri Judith A Miskei Zsanett Kover Alexandra Steinerbrunner-Nagy Kinga Kardos Peter Maroti Judit E Pongracz |
| author_facet | Judit Bovari-Biri Judith A Miskei Zsanett Kover Alexandra Steinerbrunner-Nagy Kinga Kardos Peter Maroti Judit E Pongracz |
| author_sort | Judit Bovari-Biri |
| collection | DOAJ |
| description | Maxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds have shown promise in addressing these challenges, regenerating bone in this region remains complex due to its irregular shape, intricate structure, and differing cellular origins compared to other bones in the human body. Moreover, the significant and variable mechanical loads placed on the maxillofacial bones add further complexity, especially in cases of difficult-to-treat medical conditions. This review provides a brief overview of medication-related osteonecrosis of the jaw (MRONJ), highlighting the medication-induced adverse reactions and the associated clinical challenges in treating this condition. The purpose of this manuscript is to emphasize the role of biotechnology and tissue engineering technologies in therapy. By using scaffold materials and biofactors in combination with autologous cells, innovative solutions are explored for the repair of damaged facial bones. The ongoing search for effective scaffolds that can address these challenges and improve in vitro bone preparation for subsequent regeneration in the maxillofacial region remains critical. The primary purpose of this review is to spotlight current research trends and novel approaches in this area. |
| format | Article |
| id | doaj-art-6c5fbf48be7e4850bb98de78b399853a |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-6c5fbf48be7e4850bb98de78b399853a2025-01-24T13:26:50ZengMDPI AGCells2073-44092025-01-0114214510.3390/cells14020145Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ)Judit Bovari-Biri0Judith A Miskei1Zsanett Kover2Alexandra Steinerbrunner-Nagy3Kinga Kardos4Peter Maroti5Judit E Pongracz6Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 7624 Pecs, HungaryDepartment of Maxillo-Facial Surgery, Clinical Centre, The Medical School, University of Pecs, 7624 Pecs, HungaryDepartment of Maxillo-Facial Surgery, Clinical Centre, The Medical School, University of Pecs, 7624 Pecs, HungaryDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 7624 Pecs, Hungary3D Printing and Visualization Centre, University of Pecs, 7624 Pecs, Hungary3D Printing and Visualization Centre, University of Pecs, 7624 Pecs, HungaryDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 7624 Pecs, HungaryMaxillofacial bone defects can have a profound impact on both facial function and aesthetics. While various biomaterial scaffolds have shown promise in addressing these challenges, regenerating bone in this region remains complex due to its irregular shape, intricate structure, and differing cellular origins compared to other bones in the human body. Moreover, the significant and variable mechanical loads placed on the maxillofacial bones add further complexity, especially in cases of difficult-to-treat medical conditions. This review provides a brief overview of medication-related osteonecrosis of the jaw (MRONJ), highlighting the medication-induced adverse reactions and the associated clinical challenges in treating this condition. The purpose of this manuscript is to emphasize the role of biotechnology and tissue engineering technologies in therapy. By using scaffold materials and biofactors in combination with autologous cells, innovative solutions are explored for the repair of damaged facial bones. The ongoing search for effective scaffolds that can address these challenges and improve in vitro bone preparation for subsequent regeneration in the maxillofacial region remains critical. The primary purpose of this review is to spotlight current research trends and novel approaches in this area.https://www.mdpi.com/2073-4409/14/2/145MRONJbone scaffoldscellularizationstimulation of bone differentiation |
| spellingShingle | Judit Bovari-Biri Judith A Miskei Zsanett Kover Alexandra Steinerbrunner-Nagy Kinga Kardos Peter Maroti Judit E Pongracz Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) Cells MRONJ bone scaffolds cellularization stimulation of bone differentiation |
| title | Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) |
| title_full | Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) |
| title_fullStr | Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) |
| title_full_unstemmed | Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) |
| title_short | Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ) |
| title_sort | advancements in bone replacement techniques potential uses after maxillary and mandibular resections due to medication related osteonecrosis of the jaw mronj |
| topic | MRONJ bone scaffolds cellularization stimulation of bone differentiation |
| url | https://www.mdpi.com/2073-4409/14/2/145 |
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