Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study
We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2016/5079675 |
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| author | Sumihisa Orita Masaomi Yamashita Yawara Eguchi Miyako Suzuki Gen Inoue Masayuki Miyagi Tomoko Watanabe Tomoyuki Ozawa Hiroto Kamoda Tetsuhiro Ishikawa Yasuchika Aoki Toshinori Ito Go Kubota Munetaka Suzuki Kazuyo Yamauchi Eiji Hanaoka Yoshihiro Sakuma Jun Shimbo Yasuhiro Oikawa Takane Suzuki Kazuhisa Takahashi Seiji Ohtori |
| author_facet | Sumihisa Orita Masaomi Yamashita Yawara Eguchi Miyako Suzuki Gen Inoue Masayuki Miyagi Tomoko Watanabe Tomoyuki Ozawa Hiroto Kamoda Tetsuhiro Ishikawa Yasuchika Aoki Toshinori Ito Go Kubota Munetaka Suzuki Kazuyo Yamauchi Eiji Hanaoka Yoshihiro Sakuma Jun Shimbo Yasuhiro Oikawa Takane Suzuki Kazuhisa Takahashi Seiji Ohtori |
| author_sort | Sumihisa Orita |
| collection | DOAJ |
| description | We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) for at least a month. NeP was identified using screening tool, Pain DETECT questionnaire. Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were assessed before and 6 weeks after PGB treatment initiation. Changes in IMC distance and adverse events were also recorded. PGB significantly improved their VAS scores for pain and sleep quality (P<0.001). With respect to JOABPEQ, significant improvements were observed with regard to the following dimensions: pain-related disorders (P<0.01), lumbar spine dysfunction (P=0.031), gait disturbance (P=0.028), and psychological disorders (P=0.014). The IMC distance showed an improvement tendency after PGB treatment, albeit with no significance (P=0.063). Minor adverse events such as dizziness were observed. PGB can be effective for neuropathic leg pain refractory to NSAIDs in LSS patients, resulting in not only pain control but also improving lower back pain-related ADL/QOL scores. |
| format | Article |
| id | doaj-art-6c2a2081e66a4f608aac6c86d6b6d103 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-6c2a2081e66a4f608aac6c86d6b6d1032025-02-03T06:45:29ZengWileyPain Research and Management1203-67651918-15232016-01-01201610.1155/2016/50796755079675Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective StudySumihisa Orita0Masaomi Yamashita1Yawara Eguchi2Miyako Suzuki3Gen Inoue4Masayuki Miyagi5Tomoko Watanabe6Tomoyuki Ozawa7Hiroto Kamoda8Tetsuhiro Ishikawa9Yasuchika Aoki10Toshinori Ito11Go Kubota12Munetaka Suzuki13Kazuyo Yamauchi14Eiji Hanaoka15Yoshihiro Sakuma16Jun Shimbo17Yasuhiro Oikawa18Takane Suzuki19Kazuhisa Takahashi20Seiji Ohtori21Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Japan Community Health Care Organization Funabashi Central Hospital, Funabashi 273-0021, JapanDepartment of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido 284-0003, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Kitasato University, Sagamihara 252-0375, JapanDepartment of Orthopaedic Surgery, Kitasato University, Sagamihara 252-0375, JapanDepartment of Orthopaedic Surgery, Tsuga Saito Orthopaedic Clinic, Chiba 264-0025, JapanDepartment of Orthopaedic Surgery, Showa University, Tokyo 142-8666, JapanDepartment of Orthopaedic Surgery, Chiba Cancer Center, Chiba 260-0801, JapanDepartment of Orthopaedic Surgery, Sanmu Medical Center, Sanmu 289-1326, JapanDepartment of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane 283-8686, JapanDepartment of Orthopaedic Surgery, Kumagaya General Hospital, Kumagaya 360-0013, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido 284-0003, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Japan Community Health Care Organization Chiba Hospital, Chiba 260-8710, JapanDepartment of Orthopaedic Surgery, Chiba National Medical Center, Chiba 260-0042, JapanDepartment of Orthopaedic Surgery, Funabashi Municipal Medical Center, Funabashi 273-8588, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanWe investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) for at least a month. NeP was identified using screening tool, Pain DETECT questionnaire. Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were assessed before and 6 weeks after PGB treatment initiation. Changes in IMC distance and adverse events were also recorded. PGB significantly improved their VAS scores for pain and sleep quality (P<0.001). With respect to JOABPEQ, significant improvements were observed with regard to the following dimensions: pain-related disorders (P<0.01), lumbar spine dysfunction (P=0.031), gait disturbance (P=0.028), and psychological disorders (P=0.014). The IMC distance showed an improvement tendency after PGB treatment, albeit with no significance (P=0.063). Minor adverse events such as dizziness were observed. PGB can be effective for neuropathic leg pain refractory to NSAIDs in LSS patients, resulting in not only pain control but also improving lower back pain-related ADL/QOL scores.http://dx.doi.org/10.1155/2016/5079675 |
| spellingShingle | Sumihisa Orita Masaomi Yamashita Yawara Eguchi Miyako Suzuki Gen Inoue Masayuki Miyagi Tomoko Watanabe Tomoyuki Ozawa Hiroto Kamoda Tetsuhiro Ishikawa Yasuchika Aoki Toshinori Ito Go Kubota Munetaka Suzuki Kazuyo Yamauchi Eiji Hanaoka Yoshihiro Sakuma Jun Shimbo Yasuhiro Oikawa Takane Suzuki Kazuhisa Takahashi Seiji Ohtori Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study Pain Research and Management |
| title | Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study |
| title_full | Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study |
| title_fullStr | Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study |
| title_full_unstemmed | Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study |
| title_short | Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study |
| title_sort | pregabalin for refractory radicular leg pain due to lumbar spinal stenosis a preliminary prospective study |
| url | http://dx.doi.org/10.1155/2016/5079675 |
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