Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity

Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity

Abstract Background Tau is an intracellular protein that plays a crucial role in stabilizing microtubules. However, it can aggregate into various forms under pathological conditions and be secreted into the brain parenchyma. While the consequences of tau aggregation within neurons have been extensiv...

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Main Authors: Valentin Zufferey, Aatmika Barve, Enea Parietti, Luc Belinga, Audrey Bringaud, Yvan Varisco, Kerstin Fabbri, Francesca Capotosti, Paola Bezzi, Nicole Déglon, Pierre Marquet, Nicolas Preitner, Kevin Richetin
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Translational Neurodegeneration
Subjects:
Tau
Mitochondria
Astrocytes
Synapse
Live imaging microscopy
Online Access:https://doi.org/10.1186/s40035-025-00474-9
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