Severe Atelectasis due to Aspirated Valproic Acid Tablet
A 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum productio...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2024/6650141 |
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| _version_ | 1832559697306058752 |
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| author | Tomomi Tanigaki Takunori Ogawa Sakika Nomura Koki Ito Yuhei Kurata Akira Matsukida Morio Ishihara Aihide Yoshino Akihiko Kawana Yoshifumi Kimizuka |
| author_facet | Tomomi Tanigaki Takunori Ogawa Sakika Nomura Koki Ito Yuhei Kurata Akira Matsukida Morio Ishihara Aihide Yoshino Akihiko Kawana Yoshifumi Kimizuka |
| author_sort | Tomomi Tanigaki |
| collection | DOAJ |
| description | A 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum production did not recur. We hypothesized that the aspirated VPA tablet increased the expression of mucin-related genes, thereby increasing mucus production. Our in vitro experiments using a human respiratory epithelial cell line revealed that VPA directly upregulates the airway mucin-related genes. We believe that this is the first case report of aspirated VPA-induced severe atelectasis and respiratory failure, which were successfully treated with the bronchoscopic removal of the VPA tablet. |
| format | Article |
| id | doaj-art-6c10fc5caea54debb396b8deeac6eea3 |
| institution | Kabale University |
| issn | 2090-6854 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-6c10fc5caea54debb396b8deeac6eea32025-02-03T01:29:27ZengWileyCase Reports in Pulmonology2090-68542024-01-01202410.1155/2024/6650141Severe Atelectasis due to Aspirated Valproic Acid TabletTomomi Tanigaki0Takunori Ogawa1Sakika Nomura2Koki Ito3Yuhei Kurata4Akira Matsukida5Morio Ishihara6Aihide Yoshino7Akihiko Kawana8Yoshifumi Kimizuka9Division of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineDivision of PsychiatryDivision of PsychiatryDivision of Infectious Diseases and Respiratory MedicineDivision of Infectious Diseases and Respiratory MedicineA 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum production did not recur. We hypothesized that the aspirated VPA tablet increased the expression of mucin-related genes, thereby increasing mucus production. Our in vitro experiments using a human respiratory epithelial cell line revealed that VPA directly upregulates the airway mucin-related genes. We believe that this is the first case report of aspirated VPA-induced severe atelectasis and respiratory failure, which were successfully treated with the bronchoscopic removal of the VPA tablet.http://dx.doi.org/10.1155/2024/6650141 |
| spellingShingle | Tomomi Tanigaki Takunori Ogawa Sakika Nomura Koki Ito Yuhei Kurata Akira Matsukida Morio Ishihara Aihide Yoshino Akihiko Kawana Yoshifumi Kimizuka Severe Atelectasis due to Aspirated Valproic Acid Tablet Case Reports in Pulmonology |
| title | Severe Atelectasis due to Aspirated Valproic Acid Tablet |
| title_full | Severe Atelectasis due to Aspirated Valproic Acid Tablet |
| title_fullStr | Severe Atelectasis due to Aspirated Valproic Acid Tablet |
| title_full_unstemmed | Severe Atelectasis due to Aspirated Valproic Acid Tablet |
| title_short | Severe Atelectasis due to Aspirated Valproic Acid Tablet |
| title_sort | severe atelectasis due to aspirated valproic acid tablet |
| url | http://dx.doi.org/10.1155/2024/6650141 |
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