Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study
Background Previous studies have shown that intravenous normal saline (NS) may be associated with the incidence of acute kidney injury (AKI). This study aimed to evaluate the association between the volume of NS infusion and AKI in heat stroke (HS) patients.Methods This multicenter retrospective coh...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294151 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591100350562304 |
|---|---|
| author | Lan Chen Junlu Zhao Liyun Lu Zhumei Gong Shuying Xu Xiaoling Yang Yuping Zhang Xiuqin Feng |
| author_facet | Lan Chen Junlu Zhao Liyun Lu Zhumei Gong Shuying Xu Xiaoling Yang Yuping Zhang Xiuqin Feng |
| author_sort | Lan Chen |
| collection | DOAJ |
| description | Background Previous studies have shown that intravenous normal saline (NS) may be associated with the incidence of acute kidney injury (AKI). This study aimed to evaluate the association between the volume of NS infusion and AKI in heat stroke (HS) patients.Methods This multicenter retrospective cohort study included 138 patients with HS. The primary outcome was the incidence of AKI. Secondary outcomes included the need for continuous renal replacement therapy (CRRT), admission to the intensive care unit (ICU), length of stay in the ICU and hospital, and in-hospital mortality. Multivariate regression models, random forest imputation, and genetic and propensity score matching were used to explore the relationship between NS infusion and outcomes.Results The mean volume of NS infusion in the emergency department (ED) was 3.02 ± 1.45 L. During hospitalization, 33 patients (23.91%) suffered from AKI. In the multivariate model, as a continuous variable (per 1 L), the volume of NS infusion was associated with the incidence of AKI (OR, 2.51; 95% CI, 1.43–4.40; p = .001), admission to the ICU (OR, 3.46; 95% CI 1.58–7.54; p = .002), and length of stay in the ICU (β, 1.00 days; 95% CI, 0.44–1.56; p < .001) and hospital (β, 1.41 days; 95% CI, 0.37–2.45; p = .008). These relationships also existed in the forest imputation cohort and matching cohort. There were no differences in the use of CRRT or in-hospital mortality.Conclusions The volume of NS infusion was associated with a significant increase in the incidence of AKI, admission to the ICU, and length of stay in the ICU and hospital among patients with HS. |
| format | Article |
| id | doaj-art-6c0eaa696f5c4ed9a236d0192f8de6fa |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-6c0eaa696f5c4ed9a236d0192f8de6fa2025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2294151Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective studyLan Chen0Junlu Zhao1Liyun Lu2Zhumei Gong3Shuying Xu4Xiaoling Yang5Yuping Zhang6Xiuqin Feng7Nursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaEmergency Department, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua Municipal Central Hospital, Jinhua, ChinaEmergency Department, Jinhua People’s Hospital, Jinhua, ChinaEmergency Department, Yiwu Central Hospital, Yiwu, ChinaEmergency Department, Dongyang People’s Hospital, Dongyang, ChinaEmergency Department, Lanxi People’s Hospital, Lanxi, ChinaNursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaNursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaBackground Previous studies have shown that intravenous normal saline (NS) may be associated with the incidence of acute kidney injury (AKI). This study aimed to evaluate the association between the volume of NS infusion and AKI in heat stroke (HS) patients.Methods This multicenter retrospective cohort study included 138 patients with HS. The primary outcome was the incidence of AKI. Secondary outcomes included the need for continuous renal replacement therapy (CRRT), admission to the intensive care unit (ICU), length of stay in the ICU and hospital, and in-hospital mortality. Multivariate regression models, random forest imputation, and genetic and propensity score matching were used to explore the relationship between NS infusion and outcomes.Results The mean volume of NS infusion in the emergency department (ED) was 3.02 ± 1.45 L. During hospitalization, 33 patients (23.91%) suffered from AKI. In the multivariate model, as a continuous variable (per 1 L), the volume of NS infusion was associated with the incidence of AKI (OR, 2.51; 95% CI, 1.43–4.40; p = .001), admission to the ICU (OR, 3.46; 95% CI 1.58–7.54; p = .002), and length of stay in the ICU (β, 1.00 days; 95% CI, 0.44–1.56; p < .001) and hospital (β, 1.41 days; 95% CI, 0.37–2.45; p = .008). These relationships also existed in the forest imputation cohort and matching cohort. There were no differences in the use of CRRT or in-hospital mortality.Conclusions The volume of NS infusion was associated with a significant increase in the incidence of AKI, admission to the ICU, and length of stay in the ICU and hospital among patients with HS.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294151Normal salineacute kidney injuryserum chlorideheat strokeemergency department |
| spellingShingle | Lan Chen Junlu Zhao Liyun Lu Zhumei Gong Shuying Xu Xiaoling Yang Yuping Zhang Xiuqin Feng Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study Renal Failure Normal saline acute kidney injury serum chloride heat stroke emergency department |
| title | Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study |
| title_full | Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study |
| title_fullStr | Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study |
| title_full_unstemmed | Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study |
| title_short | Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study |
| title_sort | association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients a multicenter retrospective study |
| topic | Normal saline acute kidney injury serum chloride heat stroke emergency department |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2294151 |
| work_keys_str_mv | AT lanchen associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT junluzhao associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT liyunlu associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT zhumeigong associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT shuyingxu associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT xiaolingyang associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT yupingzhang associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy AT xiuqinfeng associationbetweennormalsalineinfusionvolumeintheemergencydepartmentandacutekidneyinjuryinheatstrokepatientsamulticenterretrospectivestudy |