Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma
Hemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anapl...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/384123 |
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| author | Aneesh Basheer Somanath Padhi Ramesh Nagarajan Vinoth Boopathy Sudhagar Mookkappan Nayyar Iqbal |
| author_facet | Aneesh Basheer Somanath Padhi Ramesh Nagarajan Vinoth Boopathy Sudhagar Mookkappan Nayyar Iqbal |
| author_sort | Aneesh Basheer |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anaplastic large cell lymphoma (ALCL) is known, its occurrence in primary cutaneous ALCL (C-ALCL) is distinctly rare. We aim to describe a case of C-ALCL (anaplastic lymphoma kinase (ALK)−) in an elderly male who succumbed to the complication of associated HLH, which was possibly triggered by coexistent virus infection. We briefly present the literatures on lymphoma associated HLH and discuss the histopathological differentials of cutaneous CD30+ lymphoproliferative disorders. We do suggest that HLH may pose diagnostic challenges in the evaluation of an underlying lymphoma and hence warrants proper evaluation for the underlying etiologies and/or triggering factors. |
| format | Article |
| id | doaj-art-6c0e4b980efe401ea22b08e0f51ff24d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6c0e4b980efe401ea22b08e0f51ff24d2025-02-03T01:12:17ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/384123384123Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell LymphomaAneesh Basheer0Somanath Padhi1Ramesh Nagarajan2Vinoth Boopathy3Sudhagar Mookkappan4Nayyar Iqbal5Pondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaPondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaPondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaPondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaPondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaPondicherry Institute of Medical Sciences, Ganapathichettikulam, Pondicherry 605014, IndiaHemophagocytic lymphohistiocytosis (HLH) has a well known association with lymphomas, especially of T cell origin. Prognosis of lymphoma associated HLH is very poor, especially in T cell lymphomas; and, therefore, early diagnosis might alter the outcome. Though association of HLH with systemic anaplastic large cell lymphoma (ALCL) is known, its occurrence in primary cutaneous ALCL (C-ALCL) is distinctly rare. We aim to describe a case of C-ALCL (anaplastic lymphoma kinase (ALK)−) in an elderly male who succumbed to the complication of associated HLH, which was possibly triggered by coexistent virus infection. We briefly present the literatures on lymphoma associated HLH and discuss the histopathological differentials of cutaneous CD30+ lymphoproliferative disorders. We do suggest that HLH may pose diagnostic challenges in the evaluation of an underlying lymphoma and hence warrants proper evaluation for the underlying etiologies and/or triggering factors.http://dx.doi.org/10.1155/2014/384123 |
| spellingShingle | Aneesh Basheer Somanath Padhi Ramesh Nagarajan Vinoth Boopathy Sudhagar Mookkappan Nayyar Iqbal Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma Case Reports in Hematology |
| title | Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma |
| title_full | Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma |
| title_fullStr | Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma |
| title_full_unstemmed | Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma |
| title_short | Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma |
| title_sort | hemophagocytic lymphohistiocytosis in association with primary cutaneous anaplastic large cell lymphoma |
| url | http://dx.doi.org/10.1155/2014/384123 |
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