Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. Other etiological factors include immune suppression, organ transplantation, and polyoma virus infecti...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/176173 |
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| _version_ | 1832550357649063936 |
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| author | Eric P. Arruda Kevin M. Higgins |
| author_facet | Eric P. Arruda Kevin M. Higgins |
| author_sort | Eric P. Arruda |
| collection | DOAJ |
| description | Merkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. Other etiological factors include immune suppression, organ transplantation, and polyoma virus infection. MCC has a propensity to spread to regional lymphatics with a high locoregional recurrence rate. Since its discovery in 1972, treatment paradigms have shifted, with no consensus on optimal management strategies. Currently, standard of care includes surgical intervention to the primary and locoregional site with adjuvant radiotherapy for high-risk disease. In this paper, we discuss the history, pathology, and epidemiology of this rare disease with a focus on the evidentiary basis of treatment protocols. The use of sentinel lymph node biopsy as a management option will be the focus of this paper. |
| format | Article |
| id | doaj-art-6bfe03751bb947a59c02fb9b3b2b0314 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-6bfe03751bb947a59c02fb9b3b2b03142025-02-03T06:06:59ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/176173176173Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell CarcinomaEric P. Arruda0Kevin M. Higgins1Head and Neck Surgery, Department of Otolaryngology, University of Toronto, Toronto, ON, M5G 2N2, CanadaHead and Neck Surgery, Department of Otolaryngology, University of Toronto, Toronto, ON, M5G 2N2, CanadaMerkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. Other etiological factors include immune suppression, organ transplantation, and polyoma virus infection. MCC has a propensity to spread to regional lymphatics with a high locoregional recurrence rate. Since its discovery in 1972, treatment paradigms have shifted, with no consensus on optimal management strategies. Currently, standard of care includes surgical intervention to the primary and locoregional site with adjuvant radiotherapy for high-risk disease. In this paper, we discuss the history, pathology, and epidemiology of this rare disease with a focus on the evidentiary basis of treatment protocols. The use of sentinel lymph node biopsy as a management option will be the focus of this paper.http://dx.doi.org/10.1155/2012/176173 |
| spellingShingle | Eric P. Arruda Kevin M. Higgins Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma Journal of Skin Cancer |
| title | Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma |
| title_full | Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma |
| title_fullStr | Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma |
| title_full_unstemmed | Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma |
| title_short | Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma |
| title_sort | role of sentinel lymph node biopsy in the management of merkel cell carcinoma |
| url | http://dx.doi.org/10.1155/2012/176173 |
| work_keys_str_mv | AT ericparruda roleofsentinellymphnodebiopsyinthemanagementofmerkelcellcarcinoma AT kevinmhiggins roleofsentinellymphnodebiopsyinthemanagementofmerkelcellcarcinoma |