Current Overview of Allergens of Plant Pathogenesis Related Protein Families
Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, som...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/543195 |
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| author | Mau Sinha Rashmi Prabha Singh Gajraj Singh Kushwaha Naseer Iqbal Avinash Singh Sanket Kaushik Punit Kaur Sujata Sharma Tej P. Singh |
| author_facet | Mau Sinha Rashmi Prabha Singh Gajraj Singh Kushwaha Naseer Iqbal Avinash Singh Sanket Kaushik Punit Kaur Sujata Sharma Tej P. Singh |
| author_sort | Mau Sinha |
| collection | DOAJ |
| description | Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens. |
| format | Article |
| id | doaj-art-6bfd7ed4392b4cde95baec2db990e594 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6bfd7ed4392b4cde95baec2db990e5942025-02-03T06:11:31ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/543195543195Current Overview of Allergens of Plant Pathogenesis Related Protein FamiliesMau Sinha0Rashmi Prabha Singh1Gajraj Singh Kushwaha2Naseer Iqbal3Avinash Singh4Sanket Kaushik5Punit Kaur6Sujata Sharma7Tej P. Singh8Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaPathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.http://dx.doi.org/10.1155/2014/543195 |
| spellingShingle | Mau Sinha Rashmi Prabha Singh Gajraj Singh Kushwaha Naseer Iqbal Avinash Singh Sanket Kaushik Punit Kaur Sujata Sharma Tej P. Singh Current Overview of Allergens of Plant Pathogenesis Related Protein Families The Scientific World Journal |
| title | Current Overview of Allergens of Plant Pathogenesis Related Protein Families |
| title_full | Current Overview of Allergens of Plant Pathogenesis Related Protein Families |
| title_fullStr | Current Overview of Allergens of Plant Pathogenesis Related Protein Families |
| title_full_unstemmed | Current Overview of Allergens of Plant Pathogenesis Related Protein Families |
| title_short | Current Overview of Allergens of Plant Pathogenesis Related Protein Families |
| title_sort | current overview of allergens of plant pathogenesis related protein families |
| url | http://dx.doi.org/10.1155/2014/543195 |
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