ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confou...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/3465351 |
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| author | Uroosa Ibrahim Amina Saqib Maryam Rehan Jean Paul Atallah |
| author_facet | Uroosa Ibrahim Amina Saqib Maryam Rehan Jean Paul Atallah |
| author_sort | Uroosa Ibrahim |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. We present a case of a 69-year-old female who presented with dyspnea and malaise. Her condition declined rapidly with laboratory parameters consistent with DIC. In addition, she had a ferritin of 32,522 ng/mL, low haptoglobin, and elevated LDH, and bone marrow biopsy showed hemophagocytic lymphohistiocytes. She was started on HLH-directed therapy, and later, a diagnosis of ALK-negative anaplastic large cell lymphoma was made on an excisional inguinal lymph node biopsy specimen. Our case emphasizes the importance of prompt recognition, diagnosis, and treatment of HLH while workup for a primary disorder is still being pursued. |
| format | Article |
| id | doaj-art-6bfb45543eac4d048f99722522a2f39c |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6bfb45543eac4d048f99722522a2f39c2025-02-03T05:57:32ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/34653513465351ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal PresentationUroosa Ibrahim0Amina Saqib1Maryam Rehan2Jean Paul Atallah3Department of Hematology and Oncology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, New York, NY 10305, USADepartment of Pulmonary and Critical Care, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, New York, NY 10305, USADepartment of Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, New York, NY 10305, USADepartment of Hematology and Oncology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, New York, NY 10305, USAHemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. We present a case of a 69-year-old female who presented with dyspnea and malaise. Her condition declined rapidly with laboratory parameters consistent with DIC. In addition, she had a ferritin of 32,522 ng/mL, low haptoglobin, and elevated LDH, and bone marrow biopsy showed hemophagocytic lymphohistiocytes. She was started on HLH-directed therapy, and later, a diagnosis of ALK-negative anaplastic large cell lymphoma was made on an excisional inguinal lymph node biopsy specimen. Our case emphasizes the importance of prompt recognition, diagnosis, and treatment of HLH while workup for a primary disorder is still being pursued.http://dx.doi.org/10.1155/2018/3465351 |
| spellingShingle | Uroosa Ibrahim Amina Saqib Maryam Rehan Jean Paul Atallah ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation Case Reports in Hematology |
| title | ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation |
| title_full | ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation |
| title_fullStr | ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation |
| title_full_unstemmed | ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation |
| title_short | ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation |
| title_sort | alk negative anaplastic large cell lymphoma presenting as disseminated intravascular coagulation and hemophagocytic lymphohistiocytosis a potentially fatal presentation |
| url | http://dx.doi.org/10.1155/2018/3465351 |
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