Aberrant Expression of CYP2W1 in Pediatric Soft Tissue Sarcomas: Clinical Significance and Potential as a Therapeutic Target

Aberrant Expression of CYP2W1 in Pediatric Soft Tissue Sarcomas: Clinical Significance and Potential as a Therapeutic Target

Pediatric soft-tissue sarcomas (STSs) are aggressive malignancies with poor prognoses, particularly in recurrent and metastatic cases. Standard therapies, such as cytotoxic chemotherapy, offer limited survival benefits and carry significant toxicities, underscoring the urgent need for innovative the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dora Molina-Ortiz, Carmen Torres-Zárate, Rocío Cárdenas-Cardós, Daniel Hernández-Arrazola, Marco R. Aguilar-Ortiz, José Palacios-Acosta, Jaime Shalkow-Klincovstein, Víctor Dorado-González, Rebeca Santes-Palacios, Elizabeth Hernández-Urzúa, Araceli Vences-Mejía
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Current Oncology
Subjects:	pediatric patients soft-tissue sarcomas (STSs) cytochrome P450 2W1 (CYP2W1) aberrant expression therapeutic target STS subtypes
Online Access:	https://www.mdpi.com/1718-7729/32/3/131
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava
by: Mengtao Li, et al.
Published: (2025-02-01)

Expression profiles of CYP1A1 and CYP1B1 enzymes in Non-small Cell Lung Cancer of Turkish Patients
by: H. Bayram, et al.
Published: (2025-03-01)

Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations
by: D. E. Ivanoshchuk, et al.
Published: (2020-12-01)

Role of CYP2D6 Gene Variants and Family History in Personalized Antidepressant Treatments for Depression
by: Minji KO, et al.
Published: (2025-03-01)

Environmentally persistent free radicals lead to selective inhibition of CYP1 monooxygenase activities, and increased production of reactive oxygen species by reaction uncoupling
by: J. Patrick Connick, et al.
Published: (2025-06-01)

The Influence of CYP2B6 Variants and Administration of Propofol on Patient Outcomes after Traumatic Brain Injury
by: Katherine O’Meara, et al.
Published: (2024-11-01)

The Cytochrome CYP4 in Breast and Other Cancers
by: Gloria M. Calaf, et al.
Published: (2025-07-01)

Probing Autism and ADHD subtypes using cortical signatures of the T1w/T2w-ratio and morphometry
by: Linn B. Norbom, et al.
Published: (2025-01-01)

<i>Tn</i>P and AHR-CYP1A1 Signaling Crosstalk in an Injury-Induced Zebrafish Inflammation Model
by: Geonildo Rodrigo Disner, et al.
Published: (2024-08-01)

Impact of <i>CYP2C9, CYP2C19</i> and <i>ABCB1</i> genetic polymorphisms on antiepileptic drug safety and efficacy
by: N. A. Galankin, et al.
Published: (2025-05-01)

Fumonisin B<sub>1</sub> Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes
by: Changyu Cao, et al.
Published: (2025-05-01)

UvCYP503 is required for stress response and pathogenicity in Ustilaginoidea virens
by: Xiuxiu Cao, et al.
Published: (2025-12-01)

Computational journey to unveil organophosphorothioate pesticides’ metabolism: A focus on chlorpyrifos and CYP2C19 mutational landscape
by: Lorenzo Pedroni, et al.
Published: (2024-12-01)

Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms
by: Przemysław J. Danek, et al.
Published: (2021-12-01)

Interaction Between CYP1A2-Related Caffeine Metabolism and Vitamin B12/Folate Status in Patients with Metabolic Syndrome: A Novel Biomarker Axis
by: Laura Claudia Popa, et al.
Published: (2025-07-01)

Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures
by: Andrew J. Annalora, et al.
Published: (2024-11-01)

Maternal MitoQ Treatment Is Protective Against Programmed Alterations in CYP Activity Due to Antenatal Dexamethasone
by: Millicent G. A. Bennett, et al.
Published: (2025-02-01)

Analysis of CYP701A1 genes in gossypium species and functional characterization through gene silencing
by: Zhao Liang, et al.
Published: (2025-02-01)

Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children
by: B. I. Kantemirova, et al.
Published: (2020-05-01)

The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncomplicated Acute Calculous Cholecystitis Who Underwent Cholecystectomy
by: A. A. Muradyan, et al.
Published: (2020-10-01)

Characterisation of the Self‐Sufficient Cytochrome P450 CYP116B234 From Rhodococcus globerulus and Its Suggested Native Role in 2‐Hydroxyphenylacetic Acid Metabolism
by: Simran Kundral, et al.
Published: (2025-03-01)

In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition
by: Priscila Goes Camargo, et al.
Published: (2025-01-01)

Barleria extracts containing barlerin and verbascoside boost immunity and regulate CYP450 gene in prostate cancer
by: Sanit Kaewdaungdee, et al.
Published: (2025-07-01)

A pilot study on cytochrome p450 2B6 single nucleotide polymorphism among Fulani ethnic group of Northwest Nigeria.
by: Umar, M.T.*1, Abubakar, M.B. 2, Chika, A. 1, Gada, Y.A. 1
Published: (2024-01-01)

Wet granulation method in the technology of 6,8-dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-F]xanthine tablets, which increases the detoxifying function of the liver
by: A. I. Petrakov, et al.
Published: (2025-06-01)

Isoform CYP1A2, as a part of the cytochrome P450 superfamily
by: Y. G. Novickaya, et al.
Published: (2014-04-01)

Ionic Liquid 1-Octyl-3-Methylimidazolium (M8OI) Is Mono-Oxygenated by CYP3A4 and CYP3A5 in Adult Human Liver
by: Alistair C. Leitch, et al.
Published: (2024-07-01)

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1
by: Si Zou, et al.
Published: (2024-03-01)

CYP2D6-inhibiting drugs and risk of fall injury after newly initiated therapy with beta-blockers—a register-based case-crossover study
by: Karin Leander, et al.
Published: (2025-07-01)

High Antennal Expression of <i>CYP6K1</i> and <i>CYP4V2</i> Participate in the Recognition of Alarm Pheromones by <i>Solenopsis invicta</i> Buren
by: Xinyi Jiang, et al.
Published: (2025-01-01)

Activities of cytochrome P450 enzyme CYP102A16 from Bacillus sp. C3
by: LI Ze-li, et al.
Published: (2012-11-01)

Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers
by: A. D. Abdrashitov, et al.
Published: (2014-04-01)

Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating cytochrome P450 family 1 subfamily A member 1 expression
by: Min Chen, et al.
Published: (2025-04-01)

Emerging Trends in Streptococcal Toxic Shock Syndrome, Japan
by: Mugen Ujiie
Published: (2025-04-01)

CYTOCHROME P450 (CYP2C9) ACTIVENESS, EVALUATED VIA LOSARTAN TEST, AS PREDICTION MARKER FOR THE WARFARIN TREATMENT DOSAGE CHOICE IN PATIENTS WITH DELAYED OUTCOMES AFTER HEART VALVES REPLACEMENT
by: S. M. Arslanbekova, et al.
Published: (2015-10-01)

AFM-Based Monitoring of Enzymatic Activity of Individual Molecules of Cytochrome CYP102A1
by: Yuri D. Ivanov, et al.
Published: (2025-05-01)

Implications of CYP1B1 in the treatment and prognosis of breast cancer
by: Maria Carolina Stipp, et al.
Published: (2025-03-01)

Human lung organoids reveal conserved CYP1A1 and metallothionein activation in response to particulate matter exposure
by: Seri Choi, et al.
Published: (2025-09-01)

Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9
by: O. G. Gribakina, et al.
Published: (2020-04-01)

Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor
by: Amani Alsharidah, et al.
Published: (2025-07-01)