Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation
Abstract Purpose The aim of this study was to evaluate the added diagnostic value of additional second stage pelvic scanning as part of the [18F]DCFPYL PET/CT procedure in patients treated for prostate cancer (PCa) who have biochemical recurrence (BR). Materials and methods Consecutive patients with...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | EJNMMI Reports |
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| Online Access: | https://doi.org/10.1186/s41824-025-00238-8 |
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| author | Ana Rodríguez-Pajuelo Miriam Guerra-Gómez Juan Ignacio Cuenca Cuenca José María Freire-Macías José Manuel Jiménez-Hoyuela García Rosa María Álvarez-Pérez |
| author_facet | Ana Rodríguez-Pajuelo Miriam Guerra-Gómez Juan Ignacio Cuenca Cuenca José María Freire-Macías José Manuel Jiménez-Hoyuela García Rosa María Álvarez-Pérez |
| author_sort | Ana Rodríguez-Pajuelo |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study was to evaluate the added diagnostic value of additional second stage pelvic scanning as part of the [18F]DCFPYL PET/CT procedure in patients treated for prostate cancer (PCa) who have biochemical recurrence (BR). Materials and methods Consecutive patients with a diagnosis of PCa who underwent a dual-phase PSMA-PET scan between September 2022 and December 2023, were retrospectively included. We analyzed the number and maximum SUV (SUVmax) of lesions only in the pelvic region (prostate, locoregional lymph nodes and bone), based on PSMA-RADS version 2.0 and miTNM criteria. To assess the potential diagnostic benefit of additional delayed pelvic PET/CT imaging as part of the PSMA-PET procedure, the change in molecular TNM classification was evaluated after the procedure. Results Additional delayed pelvic PET/CT imaging as part of the PSMA-PET procedure resulted in a change in molecular TNM classification in 22 out of 136 patients (16.2%). The highest percentage change was obtained in the miN classification (14/22 patients), followed by the miT classification (7/22) and lastly miM (1/22). Moreover, we found that patients in whom delayed pelvic imaging resulted in a change in molecular TNM classification were significantly older and had a higher PSA level than those in whom delayed imaging did not provide additional information. Conclusions Pelvic delayed imaging in patients with biochemical recurrence of prostate cancer undergoing PET/CT with [18F]DCFPYL shows a non-negligible influence on patient staging, modifying the miTNM classification in 16.2% of cases, with pelvic lymphatic involvement benefiting the most from the dual study. |
| format | Article |
| id | doaj-art-6bd20ca31aa748c0a99998432f630e1b |
| institution | Kabale University |
| issn | 3005-074X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | EJNMMI Reports |
| spelling | doaj-art-6bd20ca31aa748c0a99998432f630e1b2025-02-02T12:05:40ZengSpringerEJNMMI Reports3005-074X2025-02-019111110.1186/s41824-025-00238-8Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluationAna Rodríguez-Pajuelo0Miriam Guerra-Gómez1Juan Ignacio Cuenca Cuenca2José María Freire-Macías3José Manuel Jiménez-Hoyuela García4Rosa María Álvarez-Pérez5Nuclear Medicine Department, University Hospital Virgen del RocíoNuclear Medicine Department, University Hospital Virgen del RocíoNuclear Medicine Department, University Hospital Virgen del RocíoNuclear Medicine Department, University Hospital Virgen del RocíoNuclear Medicine Department, University Hospital Virgen del RocíoNuclear Medicine Department, University Hospital Virgen del RocíoAbstract Purpose The aim of this study was to evaluate the added diagnostic value of additional second stage pelvic scanning as part of the [18F]DCFPYL PET/CT procedure in patients treated for prostate cancer (PCa) who have biochemical recurrence (BR). Materials and methods Consecutive patients with a diagnosis of PCa who underwent a dual-phase PSMA-PET scan between September 2022 and December 2023, were retrospectively included. We analyzed the number and maximum SUV (SUVmax) of lesions only in the pelvic region (prostate, locoregional lymph nodes and bone), based on PSMA-RADS version 2.0 and miTNM criteria. To assess the potential diagnostic benefit of additional delayed pelvic PET/CT imaging as part of the PSMA-PET procedure, the change in molecular TNM classification was evaluated after the procedure. Results Additional delayed pelvic PET/CT imaging as part of the PSMA-PET procedure resulted in a change in molecular TNM classification in 22 out of 136 patients (16.2%). The highest percentage change was obtained in the miN classification (14/22 patients), followed by the miT classification (7/22) and lastly miM (1/22). Moreover, we found that patients in whom delayed pelvic imaging resulted in a change in molecular TNM classification were significantly older and had a higher PSA level than those in whom delayed imaging did not provide additional information. Conclusions Pelvic delayed imaging in patients with biochemical recurrence of prostate cancer undergoing PET/CT with [18F]DCFPYL shows a non-negligible influence on patient staging, modifying the miTNM classification in 16.2% of cases, with pelvic lymphatic involvement benefiting the most from the dual study.https://doi.org/10.1186/s41824-025-00238-8Prostate cancerDual-phasePSMA-PET[18F]DCFPYLPSMA-RADS. |
| spellingShingle | Ana Rodríguez-Pajuelo Miriam Guerra-Gómez Juan Ignacio Cuenca Cuenca José María Freire-Macías José Manuel Jiménez-Hoyuela García Rosa María Álvarez-Pérez Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation EJNMMI Reports Prostate cancer Dual-phase PSMA-PET [18F]DCFPYL PSMA-RADS. |
| title | Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation |
| title_full | Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation |
| title_fullStr | Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation |
| title_full_unstemmed | Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation |
| title_short | Impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using [18F]DCFPYL PET/CT: a retrospective evaluation |
| title_sort | impact of delayed pelvic imaging on the staging of biochemical recurrence in prostate cancer patients using 18f dcfpyl pet ct a retrospective evaluation |
| topic | Prostate cancer Dual-phase PSMA-PET [18F]DCFPYL PSMA-RADS. |
| url | https://doi.org/10.1186/s41824-025-00238-8 |
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