Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease
Introduction. Postural instability is commonly observed in Parkinson’s disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson's...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2021/5681870 |
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| author | Yang Yu Siquan Liang Yue Wang Yanan Zhao Jiaojiao Zhao Haitao Li Jingchao Wu Yuanyuan Cheng Fan Wu Jialing Wu |
| author_facet | Yang Yu Siquan Liang Yue Wang Yanan Zhao Jiaojiao Zhao Haitao Li Jingchao Wu Yuanyuan Cheng Fan Wu Jialing Wu |
| author_sort | Yang Yu |
| collection | DOAJ |
| description | Introduction. Postural instability is commonly observed in Parkinson’s disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson's disease. Methods. Forty-three patients (9 of Hoehn and Yahr stage I, 12 of stage II, 14 of stage III, and 8 of stage IV) met the criteria for the diagnosis of idiopathic Parkinson’s disease and could stand independently for at least 10 minutes. Twelve healthy controls with no sign of parkinsonism were also recruited. Postural instability was assessed by posturography in different directions (forward, backward, right, left, forward-right, forward-left, backward-right, and backward-left). This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715). Results. All participants were able to complete the limit of stability tasks without any complications. Patients in stages II to IV exhibited smaller end point excursion and slower time to complete than controls, suggesting an impaired limit of stability. The patients in stage II exhibited a remarkable decline in most directions compared to controls, except for right and left, and forward and backward decline occurred the earliest. For patients in stage III, right was the only direction with no significant difference from controls. In stage IV patients, the limit of stability declined significantly in all directions (p<0.05). Conclusions. The postural abnormalities of Parkinson’s disease can occur at early stages, and the pattern of decline is more severe in the forward-backward direction. This trial is registered with ChiCTR1900022715. |
| format | Article |
| id | doaj-art-6bcb04799055455ca5aa5b16c6fcea14 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6bcb04799055455ca5aa5b16c6fcea142025-02-03T01:29:20ZengWileyParkinson's Disease2090-80832042-00802021-01-01202110.1155/2021/56818705681870Quantitative Analysis of Postural Instability in Patients with Parkinson’s DiseaseYang Yu0Siquan Liang1Yue Wang2Yanan Zhao3Jiaojiao Zhao4Haitao Li5Jingchao Wu6Yuanyuan Cheng7Fan Wu8Jialing Wu9Department of Neurological Rehabilitation, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurological Rehabilitation, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurological Rehabilitation, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurological Rehabilitation, Tianjin Huanhu Hosptial, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hosptial, Tianjin, ChinaIntroduction. Postural instability is commonly observed in Parkinson’s disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson's disease. Methods. Forty-three patients (9 of Hoehn and Yahr stage I, 12 of stage II, 14 of stage III, and 8 of stage IV) met the criteria for the diagnosis of idiopathic Parkinson’s disease and could stand independently for at least 10 minutes. Twelve healthy controls with no sign of parkinsonism were also recruited. Postural instability was assessed by posturography in different directions (forward, backward, right, left, forward-right, forward-left, backward-right, and backward-left). This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715). Results. All participants were able to complete the limit of stability tasks without any complications. Patients in stages II to IV exhibited smaller end point excursion and slower time to complete than controls, suggesting an impaired limit of stability. The patients in stage II exhibited a remarkable decline in most directions compared to controls, except for right and left, and forward and backward decline occurred the earliest. For patients in stage III, right was the only direction with no significant difference from controls. In stage IV patients, the limit of stability declined significantly in all directions (p<0.05). Conclusions. The postural abnormalities of Parkinson’s disease can occur at early stages, and the pattern of decline is more severe in the forward-backward direction. This trial is registered with ChiCTR1900022715.http://dx.doi.org/10.1155/2021/5681870 |
| spellingShingle | Yang Yu Siquan Liang Yue Wang Yanan Zhao Jiaojiao Zhao Haitao Li Jingchao Wu Yuanyuan Cheng Fan Wu Jialing Wu Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease Parkinson's Disease |
| title | Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease |
| title_full | Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease |
| title_fullStr | Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease |
| title_full_unstemmed | Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease |
| title_short | Quantitative Analysis of Postural Instability in Patients with Parkinson’s Disease |
| title_sort | quantitative analysis of postural instability in patients with parkinson s disease |
| url | http://dx.doi.org/10.1155/2021/5681870 |
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