Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract
Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecolo...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/4189275 |
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| author | Ryan M. Kahn Sushmita Gordhandas Eloise Chapman-Davis Elizabeth Margolskee Cathleen Matrai Amy Chadburn Ellen Ritchie |
| author_facet | Ryan M. Kahn Sushmita Gordhandas Eloise Chapman-Davis Elizabeth Margolskee Cathleen Matrai Amy Chadburn Ellen Ritchie |
| author_sort | Ryan M. Kahn |
| collection | DOAJ |
| description | Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. There is minimal literature surrounding MS and extramedullary relapse with no clear guidelines. This is a case report of a 48-year-old woman with MS involving the uterine corpus, fallopian tubes, and left ovary followed by a literature review. The overall aim is to review data regarding leukemic immune evasion and sanctuary sites in order to raise awareness as this represents an important and underrecognized hematologic malignancy in an often misdiagnosed, underrecognized site. |
| format | Article |
| id | doaj-art-6bc8ab1f08c44bc6921dcf5d227c8b12 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-6bc8ab1f08c44bc6921dcf5d227c8b122025-02-03T01:03:36ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/41892754189275Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic TractRyan M. Kahn0Sushmita Gordhandas1Eloise Chapman-Davis2Elizabeth Margolskee3Cathleen Matrai4Amy Chadburn5Ellen Ritchie6Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USADepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USADepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Weill Cornell Medical College-New York Presbyterian Hospital, New York, NY 10065, USADepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College-New York Presbyterian Hospital, New York, NY, USADepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College-New York Presbyterian Hospital, New York, NY, USADepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College-New York Presbyterian Hospital, New York, NY, USADivision of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USAMyeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. There is minimal literature surrounding MS and extramedullary relapse with no clear guidelines. This is a case report of a 48-year-old woman with MS involving the uterine corpus, fallopian tubes, and left ovary followed by a literature review. The overall aim is to review data regarding leukemic immune evasion and sanctuary sites in order to raise awareness as this represents an important and underrecognized hematologic malignancy in an often misdiagnosed, underrecognized site.http://dx.doi.org/10.1155/2019/4189275 |
| spellingShingle | Ryan M. Kahn Sushmita Gordhandas Eloise Chapman-Davis Elizabeth Margolskee Cathleen Matrai Amy Chadburn Ellen Ritchie Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract Case Reports in Oncological Medicine |
| title | Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract |
| title_full | Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract |
| title_fullStr | Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract |
| title_full_unstemmed | Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract |
| title_short | Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract |
| title_sort | acute myeloid leukemia presenting as myeloid sarcoma with a predisposition to the gynecologic tract |
| url | http://dx.doi.org/10.1155/2019/4189275 |
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