Emerging roles of ribosome translation in stem cells and stem cell therapy - a review
Abstract Stem cells differ from other somatic cells in that they possess self-renewal and differentiation potential, which endows them with unique characteristics, and have great therapeutic potential. Studies have shown that the self-renewal and differentiation potential of stem cells is regulated...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01412-y |
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| author | Yanyan Gao Linlin Guo Gaoxiang Shi Ruifang Wang Xu’an Wang Jizhong Lou |
| author_facet | Yanyan Gao Linlin Guo Gaoxiang Shi Ruifang Wang Xu’an Wang Jizhong Lou |
| author_sort | Yanyan Gao |
| collection | DOAJ |
| description | Abstract Stem cells differ from other somatic cells in that they possess self-renewal and differentiation potential, which endows them with unique characteristics, and have great therapeutic potential. Studies have shown that the self-renewal and differentiation potential of stem cells is regulated by ribosomes during protein synthesis. In this review, we discuss the translation regulation mechanisms and ribosome biogenesis in stem cells. Protein translation levels and ribosome biogenesis change dynamically during the development and differentiation of stem cells, and hierarchical translational regulation promotes stem cell differentiation. We also demonstrate that mitochondrial protein translation plays an important role in the regulation of stem cell fate. Ribosomes not only mediate the self-renewal and differentiation of stem cells through protein synthesis. They are also a key target for stem cell therapy. Understanding the mechanism of ribosome regulation in stem cells will allow better control of stem cells for their application. |
| format | Article |
| id | doaj-art-6bc886f59d4b45e598c1e236576f958d |
| institution | OA Journals |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-6bc886f59d4b45e598c1e236576f958d2025-08-20T02:00:10ZengBMCCell & Bioscience2045-37012025-05-0115111910.1186/s13578-025-01412-yEmerging roles of ribosome translation in stem cells and stem cell therapy - a reviewYanyan Gao0Linlin Guo1Gaoxiang Shi2Ruifang Wang3Xu’an Wang4Jizhong Lou5Department of Anesthesiology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical UniversityThe Affiliated Cardiovascular Hospital of Qingdao University, Qingdao UniversityDepartment of Anesthesiology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical UniversityDepartment of Anesthesiology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical UniversityDepartment of Anesthesiology, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical UniversityLaboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesAbstract Stem cells differ from other somatic cells in that they possess self-renewal and differentiation potential, which endows them with unique characteristics, and have great therapeutic potential. Studies have shown that the self-renewal and differentiation potential of stem cells is regulated by ribosomes during protein synthesis. In this review, we discuss the translation regulation mechanisms and ribosome biogenesis in stem cells. Protein translation levels and ribosome biogenesis change dynamically during the development and differentiation of stem cells, and hierarchical translational regulation promotes stem cell differentiation. We also demonstrate that mitochondrial protein translation plays an important role in the regulation of stem cell fate. Ribosomes not only mediate the self-renewal and differentiation of stem cells through protein synthesis. They are also a key target for stem cell therapy. Understanding the mechanism of ribosome regulation in stem cells will allow better control of stem cells for their application.https://doi.org/10.1186/s13578-025-01412-yStem cellRibosomeProtein translationMitochondrial ribosomal protein translationStem cell therapy |
| spellingShingle | Yanyan Gao Linlin Guo Gaoxiang Shi Ruifang Wang Xu’an Wang Jizhong Lou Emerging roles of ribosome translation in stem cells and stem cell therapy - a review Cell & Bioscience Stem cell Ribosome Protein translation Mitochondrial ribosomal protein translation Stem cell therapy |
| title | Emerging roles of ribosome translation in stem cells and stem cell therapy - a review |
| title_full | Emerging roles of ribosome translation in stem cells and stem cell therapy - a review |
| title_fullStr | Emerging roles of ribosome translation in stem cells and stem cell therapy - a review |
| title_full_unstemmed | Emerging roles of ribosome translation in stem cells and stem cell therapy - a review |
| title_short | Emerging roles of ribosome translation in stem cells and stem cell therapy - a review |
| title_sort | emerging roles of ribosome translation in stem cells and stem cell therapy a review |
| topic | Stem cell Ribosome Protein translation Mitochondrial ribosomal protein translation Stem cell therapy |
| url | https://doi.org/10.1186/s13578-025-01412-y |
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