TRIM22 governs tumorigenesis and protects against endometrial cancer-associated cachexia by inhibiting inflammatory response and adipose thermogenic activity

TRIM22 governs tumorigenesis and protects against endometrial cancer-associated cachexia by inhibiting inflammatory response and adipose thermogenic activity

Abstract Background Endometrial cancer (EC) is one of the most common cancers in women, with a short overall survival and poor prognosis. Besides the biologically aggressive EC properties, Cancer-associated cachexia is the main factor. However, the detailed mechanism underlying EC-related cachexia a...

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Bibliographic Details
Main Authors: Liping Zhang, Quanrong Li, Meiting Wu, Xiushan Feng, Weichao Dai, Peifang Chen, Dezhao Chen, Zhiqun Zheng, Xiaoyan Lin, Gang Wei
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer & Metabolism
Subjects:
Endometrial cancer
Cancer-associated cachexia
Tripartite motif-containing 22(TRIM22)
Antitumor therapy
Online Access:https://doi.org/10.1186/s40170-025-00386-2
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