Case Report: A rare pediatric case of B-cell lymphoblastic lymphoma presenting as an isolated renal mass with EWSR1::FLI1 translocation and germline CHEK2 variant

Case Report: A rare pediatric case of B-cell lymphoblastic lymphoma presenting as an isolated renal mass with EWSR1::FLI1 translocation and germline CHEK2 variant

We describe a 5-year-old boy who initially presented with a large left renal mass, suspected to be Wilms tumor (WT). However, biopsy results revealed B-cell lymphoblastic lymphoma (B-LBL) manifesting as an isolated renal mass. Tumor transcriptome analysis identified an EWSR1::FLI1 fusion, with break...

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Bibliographic Details
Main Authors: Katelyn P. Daniels, Kim E. Nichols, Arti S. Pandey, Gabriela Gheorghe, Sara Helmig, Kevin Garrett, Asim K. Bag, Hiroto Inaba, Raul Ribeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pediatrics
Subjects:
B lymphoblastic lymphoma
renal mass
EWSR1::FLI1 translocation
CHEK2
Wilms tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1569506/full
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