Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities
Diabetic nephropathy (DN) is a progressive microvascular diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction contributes to the progression of renal diseases, including DN, as it alters mitochondrial homeostasis and, in turn, affects normal kidney function. Pharma...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/1010268 |
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| author | Ping Na Zhang Meng Qi Zhou Jing Guo Hui Juan Zheng Jingyi Tang Chao Zhang Yu Ning Liu Wei Jing Liu Yao Xian Wang |
| author_facet | Ping Na Zhang Meng Qi Zhou Jing Guo Hui Juan Zheng Jingyi Tang Chao Zhang Yu Ning Liu Wei Jing Liu Yao Xian Wang |
| author_sort | Ping Na Zhang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is a progressive microvascular diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction contributes to the progression of renal diseases, including DN, as it alters mitochondrial homeostasis and, in turn, affects normal kidney function. Pharmacological regulation of mitochondrial networking is a promising therapeutic strategy for preventing and restoring renal function in DN. In this review, we have surveyed recent advances in elucidating the mitochondrial networking and signaling pathways in physiological and pathological contexts. Additionally, we have considered the contributions of nontraditional therapy that ameliorate mitochondrial dysfunction and discussed their molecular mechanism, highlighting the potential value of nontraditional therapies, such as herbal medicine and lifestyle interventions, in therapeutic interventions for DN. The generation of new insights using mitochondrial networking will facilitate further investigations on nontraditional therapies for DN. |
| format | Article |
| id | doaj-art-6b8c2e61acbe4115828720fa55c4d797 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-6b8c2e61acbe4115828720fa55c4d7972025-02-03T01:26:55ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/1010268Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic OpportunitiesPing Na Zhang0Meng Qi Zhou1Jing Guo2Hui Juan Zheng3Jingyi Tang4Chao Zhang5Yu Ning Liu6Wei Jing Liu7Yao Xian Wang8Renal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingRenal Research Institution of Beijing University of Chinese Medicine and Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingDiabetic nephropathy (DN) is a progressive microvascular diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction contributes to the progression of renal diseases, including DN, as it alters mitochondrial homeostasis and, in turn, affects normal kidney function. Pharmacological regulation of mitochondrial networking is a promising therapeutic strategy for preventing and restoring renal function in DN. In this review, we have surveyed recent advances in elucidating the mitochondrial networking and signaling pathways in physiological and pathological contexts. Additionally, we have considered the contributions of nontraditional therapy that ameliorate mitochondrial dysfunction and discussed their molecular mechanism, highlighting the potential value of nontraditional therapies, such as herbal medicine and lifestyle interventions, in therapeutic interventions for DN. The generation of new insights using mitochondrial networking will facilitate further investigations on nontraditional therapies for DN.http://dx.doi.org/10.1155/2021/1010268 |
| spellingShingle | Ping Na Zhang Meng Qi Zhou Jing Guo Hui Juan Zheng Jingyi Tang Chao Zhang Yu Ning Liu Wei Jing Liu Yao Xian Wang Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities Journal of Diabetes Research |
| title | Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities |
| title_full | Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities |
| title_fullStr | Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities |
| title_full_unstemmed | Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities |
| title_short | Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities |
| title_sort | mitochondrial dysfunction and diabetic nephropathy nontraditional therapeutic opportunities |
| url | http://dx.doi.org/10.1155/2021/1010268 |
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