Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis
Introduction. The goal of this systematic review and meta-analysis was to consolidate the available data on the role of the neutrophil to lymphocyte ratio (NLR) in predicting adnexal torsion (AT), to help guide clinical decision-making and outcomes. Methods. We used Web of Science, PubMed, and Scopu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/9680591 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549720323522560 |
|---|---|
| author | Shokoufeh Khanzadeh Hossein Tahernia Jairo Hernandez Camila Sarcone Brandon Lucke-Wold Amirhosseinn Salimi Fatemeh Tabatabaei |
| author_facet | Shokoufeh Khanzadeh Hossein Tahernia Jairo Hernandez Camila Sarcone Brandon Lucke-Wold Amirhosseinn Salimi Fatemeh Tabatabaei |
| author_sort | Shokoufeh Khanzadeh |
| collection | DOAJ |
| description | Introduction. The goal of this systematic review and meta-analysis was to consolidate the available data on the role of the neutrophil to lymphocyte ratio (NLR) in predicting adnexal torsion (AT), to help guide clinical decision-making and outcomes. Methods. We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 26, 2022. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) too for quality assessment. Results. Overall, 15 articles were included in the analysis. A random-effects model revealed that patients with AT had elevated levels of NLR compared to those with other adnexal masses (SMD=1.06, 95%CI=0.67 to 1.45, p<0.001). So, NLR had diagnostic value. In the subgroup analysis according to ethnicity, we found that Caucasian patients with AT had elevated levels of NLR compared to patients who were operated due to adnexal mass and reported as having a benign ovarian cyst, without torsion (SMD=1.12, 95%CI=0.71 to 1.54, p<0.001). However, in the case of East Asian patients, there was no difference between cases and controls (SMD=0.86, 95%CI=−0.21 to 1.94, p=0.11). The pooled sensitivity of NLR was 0.79 (95%CI=0.72–0.85), and the pooled specificity was 0.84 (95% CI, 0.74–0.91). Conclusion. In conclusion, there has been an interest in the use of NLR as a diagnostic marker for AT. |
| format | Article |
| id | doaj-art-6b7e5e3bce234c2c849f1b8885779918 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6b7e5e3bce234c2c849f1b88857799182025-02-03T06:08:44ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/9680591Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-AnalysisShokoufeh Khanzadeh0Hossein Tahernia1Jairo Hernandez2Camila Sarcone3Brandon Lucke-Wold4Amirhosseinn Salimi5Fatemeh Tabatabaei6Student Research CommitteeRanfanjan University of Medical ScienceDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryStudent Research CommitteeDepartment of Obstetrics and GynaecologyIntroduction. The goal of this systematic review and meta-analysis was to consolidate the available data on the role of the neutrophil to lymphocyte ratio (NLR) in predicting adnexal torsion (AT), to help guide clinical decision-making and outcomes. Methods. We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 26, 2022. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) too for quality assessment. Results. Overall, 15 articles were included in the analysis. A random-effects model revealed that patients with AT had elevated levels of NLR compared to those with other adnexal masses (SMD=1.06, 95%CI=0.67 to 1.45, p<0.001). So, NLR had diagnostic value. In the subgroup analysis according to ethnicity, we found that Caucasian patients with AT had elevated levels of NLR compared to patients who were operated due to adnexal mass and reported as having a benign ovarian cyst, without torsion (SMD=1.12, 95%CI=0.71 to 1.54, p<0.001). However, in the case of East Asian patients, there was no difference between cases and controls (SMD=0.86, 95%CI=−0.21 to 1.94, p=0.11). The pooled sensitivity of NLR was 0.79 (95%CI=0.72–0.85), and the pooled specificity was 0.84 (95% CI, 0.74–0.91). Conclusion. In conclusion, there has been an interest in the use of NLR as a diagnostic marker for AT.http://dx.doi.org/10.1155/2022/9680591 |
| spellingShingle | Shokoufeh Khanzadeh Hossein Tahernia Jairo Hernandez Camila Sarcone Brandon Lucke-Wold Amirhosseinn Salimi Fatemeh Tabatabaei Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis Mediators of Inflammation |
| title | Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis |
| title_full | Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis |
| title_fullStr | Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis |
| title_short | Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis |
| title_sort | predictive role of neutrophil to lymphocyte ratio in adnexal torsion a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2022/9680591 |
| work_keys_str_mv | AT shokoufehkhanzadeh predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT hosseintahernia predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT jairohernandez predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT camilasarcone predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT brandonluckewold predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT amirhosseinnsalimi predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis AT fatemehtabatabaei predictiveroleofneutrophiltolymphocyteratioinadnexaltorsionasystematicreviewandmetaanalysis |