Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks
<b>Background/Objectives:</b> Schizophrenia exhibits symptoms linked to the hippocampus and parahippocampal gyrus. This includes the entorhinal cortex (ERC) and perirhinal cortex (PRC) as anterior parts, along with the posterior segment known as the parahippocampal cortex (PHC). However,...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-08-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/15/1955 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849407683378020352 |
|---|---|
| author | Raghad M. Makhdoum Adnan A. S. Alahmadi |
| author_facet | Raghad M. Makhdoum Adnan A. S. Alahmadi |
| author_sort | Raghad M. Makhdoum |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Schizophrenia exhibits symptoms linked to the hippocampus and parahippocampal gyrus. This includes the entorhinal cortex (ERC) and perirhinal cortex (PRC) as anterior parts, along with the posterior segment known as the parahippocampal cortex (PHC). However, recent research has detailed atlases based on cytoarchitectural characteristics and the hippocampus divided into four subregions: cornu ammonis (CA), dentate gyrus (DG), subiculum (SUB), and hippocampal–amygdaloid transition (HATA). This study aimed to explore the functional connectivity (FC) changes between these hippocampal subregions and the parahippocampal gyrus structures (ERC, PRC, and PHC) as well as between hippocampal subregions and various functional brain networks in schizophrenia. <b>Methods:</b> In total, 50 individuals with schizophrenia and 50 matched healthy subjects were examined using resting state functional magnetic resonance imaging (rs-fMRI). <b>Results:</b> The results showed alterations characterized by increases and decreases in the strength of the positive connectivity between the parahippocampal gyrus structures and the four hippocampal subregions when comparing patients with schizophrenia with healthy subjects. Alterations were observed among the hippocampal subregions and functional brain networks, as well as the formation of new connections and absence of connections. <b>Conclusions:</b> There is strong evidence that the different subregions of the hippocampus have unique functions and their connectivity with the parahippocampal cortices and brain networks are affected by schizophrenia. |
| format | Article |
| id | doaj-art-6b7c0d1f3c2044e3b77ed539334c6b69 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-6b7c0d1f3c2044e3b77ed539334c6b692025-08-20T03:35:58ZengMDPI AGDiagnostics2075-44182025-08-011515195510.3390/diagnostics15151955Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain NetworksRaghad M. Makhdoum0Adnan A. S. Alahmadi1Department of Radiologic Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Radiologic Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia<b>Background/Objectives:</b> Schizophrenia exhibits symptoms linked to the hippocampus and parahippocampal gyrus. This includes the entorhinal cortex (ERC) and perirhinal cortex (PRC) as anterior parts, along with the posterior segment known as the parahippocampal cortex (PHC). However, recent research has detailed atlases based on cytoarchitectural characteristics and the hippocampus divided into four subregions: cornu ammonis (CA), dentate gyrus (DG), subiculum (SUB), and hippocampal–amygdaloid transition (HATA). This study aimed to explore the functional connectivity (FC) changes between these hippocampal subregions and the parahippocampal gyrus structures (ERC, PRC, and PHC) as well as between hippocampal subregions and various functional brain networks in schizophrenia. <b>Methods:</b> In total, 50 individuals with schizophrenia and 50 matched healthy subjects were examined using resting state functional magnetic resonance imaging (rs-fMRI). <b>Results:</b> The results showed alterations characterized by increases and decreases in the strength of the positive connectivity between the parahippocampal gyrus structures and the four hippocampal subregions when comparing patients with schizophrenia with healthy subjects. Alterations were observed among the hippocampal subregions and functional brain networks, as well as the formation of new connections and absence of connections. <b>Conclusions:</b> There is strong evidence that the different subregions of the hippocampus have unique functions and their connectivity with the parahippocampal cortices and brain networks are affected by schizophrenia.https://www.mdpi.com/2075-4418/15/15/1955schizophreniahippocampal subregionsparahippocampal gyrusfunctional connectivity |
| spellingShingle | Raghad M. Makhdoum Adnan A. S. Alahmadi Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks Diagnostics schizophrenia hippocampal subregions parahippocampal gyrus functional connectivity |
| title | Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks |
| title_full | Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks |
| title_fullStr | Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks |
| title_full_unstemmed | Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks |
| title_short | Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks |
| title_sort | disturbances in resting state functional connectivity in schizophrenia a study of hippocampal subregions the parahippocampal gyrus and functional brain networks |
| topic | schizophrenia hippocampal subregions parahippocampal gyrus functional connectivity |
| url | https://www.mdpi.com/2075-4418/15/15/1955 |
| work_keys_str_mv | AT raghadmmakhdoum disturbancesinrestingstatefunctionalconnectivityinschizophreniaastudyofhippocampalsubregionstheparahippocampalgyrusandfunctionalbrainnetworks AT adnanasalahmadi disturbancesinrestingstatefunctionalconnectivityinschizophreniaastudyofhippocampalsubregionstheparahippocampalgyrusandfunctionalbrainnetworks |