A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients
ABSTRACT The relationship between hemodynamic parameters and body mass index (BMI) in the context of blood pressure regulation in hypertension is unclear. Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14946 |
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| author | Wenqi Xiao Ping Han Liping Song Jingwen Yang Lin Zhou Xiangning Deng Zheng J. Ma Yukun Lang Hai Zhao Yuzhuo Zhao Hui Chen Wenjing Zhang Huixian Huang Ningling Sun |
| author_facet | Wenqi Xiao Ping Han Liping Song Jingwen Yang Lin Zhou Xiangning Deng Zheng J. Ma Yukun Lang Hai Zhao Yuzhuo Zhao Hui Chen Wenjing Zhang Huixian Huang Ningling Sun |
| author_sort | Wenqi Xiao |
| collection | DOAJ |
| description | ABSTRACT The relationship between hemodynamic parameters and body mass index (BMI) in the context of blood pressure regulation in hypertension is unclear. Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index (CI), arterial stiffness (AS), systemic vascular resistance index (SVRI), and thoracic blood ratio (TBR). In this cohort, the average BMI across all hypertension patients was 26.859 ± 3.897 (kg/m2), with obese patients (BMI ≥ 28 kg/m2) averaging 31.01 ± 2.87 kg/m2 and non‐obese (BMI<28 kg/m2) averaging 24.70 ± 2.28 kg/m2. Younger obese patients exhibited higher diastolic pressures than non‐obese peers (p < 0.01). Hemodynamic analysis showed obese patients had increased HR and SVRI but lower CI and AS (p < 0.01). Hypertensive males aged under 60 with obesity displayed a more prominent peripheral vascular phenotype (p < 0.05) and volemic phenotype (p < 0.01) than non‐obese males. Obese females aged under 60 showed a higher incidence of cardiac phenotype (p < 0.01). Across genders, obese hypertensive patients aged over 60 had a greater prevalence of volemic phenotype than non‐obese patients (p < 0.05, p < 0.01, respectively). BMI inversely correlated with CI and positively with SVRI across age and gender categories (p < 0.01). Taken together, we find that patients with hypertension exhibit diverse hemodynamic profiles, and BMI significantly correlates with hemodynamic parameters such as SVRI and CI. Our research identifies BMI as a valuable target for personalized hypertension treatment. |
| format | Article |
| id | doaj-art-6b797a68d2bf445b87218edc2c50b938 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-6b797a68d2bf445b87218edc2c50b9382025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14946A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive PatientsWenqi Xiao0Ping Han1Liping Song2Jingwen Yang3Lin Zhou4Xiangning Deng5Zheng J. Ma6Yukun Lang7Hai Zhao8Yuzhuo Zhao9Hui Chen10Wenjing Zhang11Huixian Huang12Ningling Sun13Department of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Peking University Third Hospital Beijing ChinaSJTU‐Yale Joint Center for Biostatistics Shanghai Jiao Tong University Shanghai ChinaQinglongqiao Community Service Center Beijing ChinaShuangyushu Community Health Service Center Beijing ChinaQingmao Community Health Service Station Beijing ChinaWenquan Town Community Health Service Center Beijing ChinaHaidian Town Community Health Service Center Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaDepartment of Cardiology Beijing Haidian Hospital Beijing ChinaABSTRACT The relationship between hemodynamic parameters and body mass index (BMI) in the context of blood pressure regulation in hypertension is unclear. Here, we analyzed data from 1368 uncontrolled hypertensive patients, including key hemodynamic indicators such as heart rate (HR), cardiac index (CI), arterial stiffness (AS), systemic vascular resistance index (SVRI), and thoracic blood ratio (TBR). In this cohort, the average BMI across all hypertension patients was 26.859 ± 3.897 (kg/m2), with obese patients (BMI ≥ 28 kg/m2) averaging 31.01 ± 2.87 kg/m2 and non‐obese (BMI<28 kg/m2) averaging 24.70 ± 2.28 kg/m2. Younger obese patients exhibited higher diastolic pressures than non‐obese peers (p < 0.01). Hemodynamic analysis showed obese patients had increased HR and SVRI but lower CI and AS (p < 0.01). Hypertensive males aged under 60 with obesity displayed a more prominent peripheral vascular phenotype (p < 0.05) and volemic phenotype (p < 0.01) than non‐obese males. Obese females aged under 60 showed a higher incidence of cardiac phenotype (p < 0.01). Across genders, obese hypertensive patients aged over 60 had a greater prevalence of volemic phenotype than non‐obese patients (p < 0.05, p < 0.01, respectively). BMI inversely correlated with CI and positively with SVRI across age and gender categories (p < 0.01). Taken together, we find that patients with hypertension exhibit diverse hemodynamic profiles, and BMI significantly correlates with hemodynamic parameters such as SVRI and CI. Our research identifies BMI as a valuable target for personalized hypertension treatment.https://doi.org/10.1111/jch.14946body mass indexhemodynamic phenotypehypertensionobese |
| spellingShingle | Wenqi Xiao Ping Han Liping Song Jingwen Yang Lin Zhou Xiangning Deng Zheng J. Ma Yukun Lang Hai Zhao Yuzhuo Zhao Hui Chen Wenjing Zhang Huixian Huang Ningling Sun A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients The Journal of Clinical Hypertension body mass index hemodynamic phenotype hypertension obese |
| title | A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients |
| title_full | A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients |
| title_fullStr | A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients |
| title_full_unstemmed | A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients |
| title_short | A Retrospective Study to Investigate the Relationship Between Body Mass Index and Hemodynamic Characteristics in Hypertensive Patients |
| title_sort | retrospective study to investigate the relationship between body mass index and hemodynamic characteristics in hypertensive patients |
| topic | body mass index hemodynamic phenotype hypertension obese |
| url | https://doi.org/10.1111/jch.14946 |
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