PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells

PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells

Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of the most important pathways implicated in prostate cancer. Previous work has shown that there is crosstalk between these two pathways; however, there are conflicting findings and the molecular mechan...

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Main Authors: Mari Kaarbø, Øyvind Løveseter Mikkelsen, Lene Malerød, Su Qu, Viola H. Lobert, Gulcan Akgul, Thomas Halvorsen, Gunhild M. Mælandsmo, Fahri Saatcioglu
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2009-0487
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