Animal Models of Diabetic Neuropathy: Progress Since 1960s
Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common w...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/149452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566542382923776 |
|---|---|
| author | Md. Shahidul Islam |
| author_facet | Md. Shahidul Islam |
| author_sort | Md. Shahidul Islam |
| collection | DOAJ |
| description | Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, streptozotocin-induced C57BL6/J and ddY mice models, Chinese hamster neuropathic model, rhesus monkey PDN model, spontaneously diabetic WBN/Kob rat model, L-fucose-induced neropathic rat model, partial sciatic nerve ligated rat model, nonobese diabetic (NOD) mice model, spontaneously induced Ins2 Akita mice model, leptin-deficient (ob/ob) mice model, Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, surgically-induced neuropathic model, and genetically modified Spontaneously Diabetic Torii (SDT) rat model, none of which are without limitations. An animal model of diabetic or PDN should mimic the all major pathogeneses of human diabetic neuropathy. Hence, this review comparatively evaluates the animal models of diabetic and PDN which are developed since 1960s with their advantages and disadvantages to help diabetic research groups in order to more accurately choose an appropriate model to meet their specific research objectives. |
| format | Article |
| id | doaj-art-6b6521b38f864fb7b67cee8d88eff421 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-6b6521b38f864fb7b67cee8d88eff4212025-02-03T01:03:47ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/149452149452Animal Models of Diabetic Neuropathy: Progress Since 1960sMd. Shahidul Islam0Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South AfricaDiabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, streptozotocin-induced C57BL6/J and ddY mice models, Chinese hamster neuropathic model, rhesus monkey PDN model, spontaneously diabetic WBN/Kob rat model, L-fucose-induced neropathic rat model, partial sciatic nerve ligated rat model, nonobese diabetic (NOD) mice model, spontaneously induced Ins2 Akita mice model, leptin-deficient (ob/ob) mice model, Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, surgically-induced neuropathic model, and genetically modified Spontaneously Diabetic Torii (SDT) rat model, none of which are without limitations. An animal model of diabetic or PDN should mimic the all major pathogeneses of human diabetic neuropathy. Hence, this review comparatively evaluates the animal models of diabetic and PDN which are developed since 1960s with their advantages and disadvantages to help diabetic research groups in order to more accurately choose an appropriate model to meet their specific research objectives.http://dx.doi.org/10.1155/2013/149452 |
| spellingShingle | Md. Shahidul Islam Animal Models of Diabetic Neuropathy: Progress Since 1960s Journal of Diabetes Research |
| title | Animal Models of Diabetic Neuropathy: Progress Since 1960s |
| title_full | Animal Models of Diabetic Neuropathy: Progress Since 1960s |
| title_fullStr | Animal Models of Diabetic Neuropathy: Progress Since 1960s |
| title_full_unstemmed | Animal Models of Diabetic Neuropathy: Progress Since 1960s |
| title_short | Animal Models of Diabetic Neuropathy: Progress Since 1960s |
| title_sort | animal models of diabetic neuropathy progress since 1960s |
| url | http://dx.doi.org/10.1155/2013/149452 |
| work_keys_str_mv | AT mdshahidulislam animalmodelsofdiabeticneuropathyprogresssince1960s |