Energy-structural status in perioperative sedoanalgesia
The use of minimally invasive surgical techniques and sedoanalgesia contributes to significant progress in reducing perioperative complications, as well as in reducing the length of stay for in-patients, but the problem of the violation of energy-structural interactions in the patient's organis...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2018-08-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/133502/136413 |
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| _version_ | 1850053550187479040 |
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| author | O. N. Boitsova |
| author_facet | O. N. Boitsova |
| author_sort | O. N. Boitsova |
| collection | DOAJ |
| description | The use of minimally invasive surgical techniques and sedoanalgesia contributes to significant progress in reducing perioperative complications, as well as in reducing the length of stay for in-patients, but the problem of the violation of energy-structural interactions in the patient's organism, which subsequently leads to disturbances of higher cortical functions, remains topical. The energy-structural status (ESS) of the organism and the central nervous system specialized cells vital activity disorders are still unexplored.
Aim. Improving treatment outcomes for patients with acute intra-abdominal diseases by giving energy-protective capacity to sedoanalgesia and perioperative management.
Materials and methods. The research was performed on the results of the perioperative energy-structural activity (ESA) audit, its reserves, properties, and the effectiveness of autoregulation in 84 patients with acute intra-abdominal diseases. According to the initial level of energy-structural activity, all patients were divided into three groups: with dysfunction of the energy-structural status, with damage and insufficiency. Each group was randomly subdivided into treatment and control groups. Patients of the control group underwent standard sedoanalgesia, and patients of the treatment group underwent sedoanalgesia with the use of energy-protective techniques. At all perioperative stages a deep picture of the oxygen regime, acid-base, water-electrolyte balance, hemodynamic and microcirculation indices, basal metabolic rate were studied. Additionally, markers of early signs of neuronal damage were determined in 10 patients: neuroglial protein S100 and neuron-specific enolase NSE.
Results. The close relationship between early manifestation of structural microdamages of brain cells and energy-structural changes in the patients' body was proved. The study of the neurospecific proteins level and dynamics of energy-structural activity parameters confirms that the use of energy-protective techniques significantly increases the perioperative energy-protective capacity of sedoanalgesia (p<0,05).
Conclusions. Supplementation of standard sedoanalgesia with energy-protective techniques allows to supply anesthetic management of urgent abdominal surgery with energy-protective properties, providing the necessary energy-structural interaction, which makes it possible to reduce the severity of energy-structural status damage, that leads to decreased severity of neurons and neuroglia intracellular damage. |
| format | Article |
| id | doaj-art-6b6014e9db0145dcba67b6143a49e00a |
| institution | DOAJ |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-6b6014e9db0145dcba67b6143a49e00a2025-08-20T02:52:30ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322018-08-01219720310.14739/2409-2932.2018.2.133502Energy-structural status in perioperative sedoanalgesiaO. N. BoitsovaThe use of minimally invasive surgical techniques and sedoanalgesia contributes to significant progress in reducing perioperative complications, as well as in reducing the length of stay for in-patients, but the problem of the violation of energy-structural interactions in the patient's organism, which subsequently leads to disturbances of higher cortical functions, remains topical. The energy-structural status (ESS) of the organism and the central nervous system specialized cells vital activity disorders are still unexplored. Aim. Improving treatment outcomes for patients with acute intra-abdominal diseases by giving energy-protective capacity to sedoanalgesia and perioperative management. Materials and methods. The research was performed on the results of the perioperative energy-structural activity (ESA) audit, its reserves, properties, and the effectiveness of autoregulation in 84 patients with acute intra-abdominal diseases. According to the initial level of energy-structural activity, all patients were divided into three groups: with dysfunction of the energy-structural status, with damage and insufficiency. Each group was randomly subdivided into treatment and control groups. Patients of the control group underwent standard sedoanalgesia, and patients of the treatment group underwent sedoanalgesia with the use of energy-protective techniques. At all perioperative stages a deep picture of the oxygen regime, acid-base, water-electrolyte balance, hemodynamic and microcirculation indices, basal metabolic rate were studied. Additionally, markers of early signs of neuronal damage were determined in 10 patients: neuroglial protein S100 and neuron-specific enolase NSE. Results. The close relationship between early manifestation of structural microdamages of brain cells and energy-structural changes in the patients' body was proved. The study of the neurospecific proteins level and dynamics of energy-structural activity parameters confirms that the use of energy-protective techniques significantly increases the perioperative energy-protective capacity of sedoanalgesia (p<0,05). Conclusions. Supplementation of standard sedoanalgesia with energy-protective techniques allows to supply anesthetic management of urgent abdominal surgery with energy-protective properties, providing the necessary energy-structural interaction, which makes it possible to reduce the severity of energy-structural status damage, that leads to decreased severity of neurons and neuroglia intracellular damage.http://pharmed.zsmu.edu.ua/article/view/133502/136413anesthesialocalconscious sedationmetabolismoxygen consumptionS 100 calcium binding protein beta subunitphosphopyruvate hydratase |
| spellingShingle | O. N. Boitsova Energy-structural status in perioperative sedoanalgesia Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki anesthesia local conscious sedation metabolism oxygen consumption S 100 calcium binding protein beta subunit phosphopyruvate hydratase |
| title | Energy-structural status in perioperative sedoanalgesia |
| title_full | Energy-structural status in perioperative sedoanalgesia |
| title_fullStr | Energy-structural status in perioperative sedoanalgesia |
| title_full_unstemmed | Energy-structural status in perioperative sedoanalgesia |
| title_short | Energy-structural status in perioperative sedoanalgesia |
| title_sort | energy structural status in perioperative sedoanalgesia |
| topic | anesthesia local conscious sedation metabolism oxygen consumption S 100 calcium binding protein beta subunit phosphopyruvate hydratase |
| url | http://pharmed.zsmu.edu.ua/article/view/133502/136413 |
| work_keys_str_mv | AT onboitsova energystructuralstatusinperioperativesedoanalgesia |