Comparison of Carbapenem vs. Amikacin Antimicrobial Therapy for Pediatric Acute Pyelonephritis Caused by Extended-Spectrum Β-Lactamase-Positive Enterobacteriaceae

Comparison of Carbapenem vs. Amikacin Antimicrobial Therapy for Pediatric Acute Pyelonephritis Caused by Extended-Spectrum Β-Lactamase-Positive Enterobacteriaceae

<b>Objectives</b>: Acute pyelonephritis (APN) caused by extended-spectrum β-lactamase (ESBL)-positive Enterobacteriaceae poses a growing therapeutic challenge in children, as carbapenems remain the mainstay of treatment even when susceptibility to alternative agents such as amikacin is d...

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Main Authors: Burcu Ceylan Cura Yayla, Tuğba Bedir Demirdağ, Anıl Tapısız, Yeşim Özdemir Atikel, Hasan Tezer, Elif Ayça Şahin, Kayhan Çağlar, Sevcan A. Bakkaloğlu, Necla Buyan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Children
Subjects:
pediatric acute pyelonephritis
extended-spectrum β-lactamase
Enterobacteriaceae
amikacin
carbapenem
Online Access:https://www.mdpi.com/2227-9067/12/7/945
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