Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases
Corticosteroid therapy for acute alcoholic hepatitis has been demonstrated to enhance survival in patients who are encephalopathic, and who do not have renal failure or gastrointestinal bleeding. However, the complications of steroid therapy in such patients have been less well documented. The autho...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1995/641296 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553551098806272 |
|---|---|
| author | Vitor Arantes Pina Michieletti Ross Cameron Jenny Heathcote Morris Sherman |
| author_facet | Vitor Arantes Pina Michieletti Ross Cameron Jenny Heathcote Morris Sherman |
| author_sort | Vitor Arantes |
| collection | DOAJ |
| description | Corticosteroid therapy for acute alcoholic hepatitis has been demonstrated to enhance survival in patients who are encephalopathic, and who do not have renal failure or gastrointestinal bleeding. However, the complications of steroid therapy in such patients have been less well documented. The authors report two patients with alcoholic liver disease who developed life-threatening infections after steroid therapy was started. The first patient initially developed diabetes followed by Fournier's gangrene of the perineum, and a lung abscess following septic emboli. The second patient had established alcoholic cirrhosis rather than alcoholic hepatitis. She developed a necrotic ulcer on the arm at the site of an intravenous line, which was infected with a rhizopus species. Despite surgical debridement the lesion progressed and contributed to her death. Treatment of alcoholic hepatitis with steroids is not innocuous, and physicians should be aware of the potential for life-threatening complications. |
| format | Article |
| id | doaj-art-6b58b87007f840cfa18a8d50c4ced058 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-6b58b87007f840cfa18a8d50c4ced0582025-02-03T05:53:46ZengWileyCanadian Journal of Gastroenterology0835-79001995-01-0192818410.1155/1995/641296Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 CasesVitor Arantes0Pina Michieletti1Ross Cameron2Jenny Heathcote3Morris Sherman4Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilDepartments of Medicine and Pathology, Faculty of Medicine, University of Toronto and the Toronto Hospital, Toronto, Ontario, CanadaDepartments of Medicine and Pathology, Faculty of Medicine, University of Toronto and the Toronto Hospital, Toronto, Ontario, CanadaDepartments of Medicine and Pathology, Faculty of Medicine, University of Toronto and the Toronto Hospital, Toronto, Ontario, CanadaDepartments of Medicine and Pathology, Faculty of Medicine, University of Toronto and the Toronto Hospital, Toronto, Ontario, CanadaCorticosteroid therapy for acute alcoholic hepatitis has been demonstrated to enhance survival in patients who are encephalopathic, and who do not have renal failure or gastrointestinal bleeding. However, the complications of steroid therapy in such patients have been less well documented. The authors report two patients with alcoholic liver disease who developed life-threatening infections after steroid therapy was started. The first patient initially developed diabetes followed by Fournier's gangrene of the perineum, and a lung abscess following septic emboli. The second patient had established alcoholic cirrhosis rather than alcoholic hepatitis. She developed a necrotic ulcer on the arm at the site of an intravenous line, which was infected with a rhizopus species. Despite surgical debridement the lesion progressed and contributed to her death. Treatment of alcoholic hepatitis with steroids is not innocuous, and physicians should be aware of the potential for life-threatening complications.http://dx.doi.org/10.1155/1995/641296 |
| spellingShingle | Vitor Arantes Pina Michieletti Ross Cameron Jenny Heathcote Morris Sherman Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases Canadian Journal of Gastroenterology |
| title | Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases |
| title_full | Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases |
| title_fullStr | Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases |
| title_full_unstemmed | Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases |
| title_short | Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases |
| title_sort | unusual infections complicating the use of steroids with severe alcoholic hepatitis report of 2 cases |
| url | http://dx.doi.org/10.1155/1995/641296 |
| work_keys_str_mv | AT vitorarantes unusualinfectionscomplicatingtheuseofsteroidswithseverealcoholichepatitisreportof2cases AT pinamichieletti unusualinfectionscomplicatingtheuseofsteroidswithseverealcoholichepatitisreportof2cases AT rosscameron unusualinfectionscomplicatingtheuseofsteroidswithseverealcoholichepatitisreportof2cases AT jennyheathcote unusualinfectionscomplicatingtheuseofsteroidswithseverealcoholichepatitisreportof2cases AT morrissherman unusualinfectionscomplicatingtheuseofsteroidswithseverealcoholichepatitisreportof2cases |